Basics of Inducible Lymphoid Organs.
Sign Up to like & getrecommendations! Published in 2020 at "Current topics in microbiology and immunology"
DOI: 10.1007/82_2020_218
Abstract: Tertiary lymphoid organs (TLOs), also known as inducible lymphoid organs, tertiary lymphoid structures, tertiary lymphoid tissues, or ectopic lymphoid organs are accumulations of cells in chronic inflammation that have been observed in most tissues in… read more here.
Keywords: lymphoid organs; inducible lymphoid; microbiology; tertiary lymphoid ... See more keywords
Expression of Tim-3 drives phenotypic and functional changes in Treg cells in secondary lymphoid organs and the tumor microenvironment
Sign Up to like & getrecommendations! Published in 2021 at "Cell reports"
DOI: 10.1016/j.celrep.2021.109699
Abstract: SUMMARY Regulatory T cells (Treg cells) are critical mediators of self-tolerance, but they can also limit effective anti-tumor immunity. Although under homeostasis a small fraction of Treg cells in lymphoid organs express the putative checkpoint… read more here.
Keywords: treg cells; lymphoid organs; expression; tim ... See more keywords
Phosphatidylserine Lipid Nanoparticles Promote Systemic RNA Delivery to Secondary Lymphoid Organs.
Sign Up to like & getrecommendations! Published in 2022 at "Nano letters"
DOI: 10.1021/acs.nanolett.2c03234
Abstract: Secondary lymphoid organs (SLOs) are an important target for mRNA delivery in various applications. While the current delivery method relies on the drainage of nanoparticles to lymph nodes by intramuscular (IM) or subcutaneous (SC) injections,… read more here.
Keywords: phosphatidylserine lipid; secondary lymphoid; lymphoid organs; slos targeting ... See more keywords
Profiling the lymphoid-resident T cell pool reveals modulation by age and microbiota
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-02458-4
Abstract: Despite being implicated in non-lymphoid tissues, non-recirculating T cells may also exist in secondary lymphoid organs (SLO). However, a detailed characterization of this lymphoid-resident T cell pool has not yet been done. Here we show… read more here.
Keywords: age; lymphoid organs; resident cell; non lymphoid ... See more keywords
Prostaglandin D2 amplifies lupus disease through basophil accumulation in lymphoid organs
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03129-8
Abstract: In systemic lupus erythematosus (SLE), autoantibody production can lead to kidney damage and failure, known as lupus nephritis. Basophils amplify the synthesis of autoantibodies by accumulating in secondary lymphoid organs. Here, we show a role… read more here.
Keywords: pgd2; accumulation; lymphoid organs; disease ... See more keywords
Immunodepression induced by influenza A virus (H1N1) in lymphoid organs functions as a pathogenic mechanism
Sign Up to like & getrecommendations! Published in 2020 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13358
Abstract: In recent years, the frequency of influenza epidemics around the world has posed a great threat to the lives of people, especially those in developing countries. However, it is unclear which organs are the targets… read more here.
Keywords: lymph nodes; lymphoid organs; histopathology; spleen hilar ... See more keywords
Tissue‐resident regulatory T cells accumulate at human barrier lymphoid organs
Sign Up to like & getrecommendations! Published in 2021 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12481
Abstract: Regulatory T cells (Tregs) play a critical role in immune regulation and peripheral tolerance. While different types of Tregs have been identified in both mice and humans, much of our understanding about how these cells… read more here.
Keywords: lymphoid organs; resident tregs; tissue resident; regulatory cells ... See more keywords
The discovery of a new type of innervation in lymphoid organs
Sign Up to like & getrecommendations! Published in 2023 at "Physiological Reports"
DOI: 10.14814/phy2.15604
Abstract: It is well known that the main forms of innervation are synapses and free nerve endings, while other forms of innervation have not been reported. Here, we explore a new way of innervating lymphoid organs.… read more here.
Keywords: innervation; discovery new; biotinylated glucan; microscopy ... See more keywords
Distribution of T-cell markers CD4 and CD8α in lymphoid organs of healthy newborn, juvenile, and adult highland-plateau yaks.
Sign Up to like & getrecommendations! Published in 2017 at "American journal of veterinary research"
DOI: 10.2460/ajvr.78.5.609
Abstract: OBJECTIVE To investigate the distribution of T-cell markers (CD4 and CD8α) in lymphoid organs of newborn, juvenile, and adult yaks. ANIMALS 15 healthy male yaks of various ages from highland plateaus. PROCEDURES Yaks were allocated… read more here.
Keywords: cd4 cd8; lymphoid organs; cell; distribution ... See more keywords
High Endothelial Venules and Other Blood Vessels: Critical Regulators of Lymphoid Organ Development and Function
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.00045
Abstract: The blood vasculature regulates both the development and function of secondary lymphoid organs by providing a portal for entry of hemopoietic cells. During the development of lymphoid organs in the embryo, blood vessels deliver lymphoid… read more here.
Keywords: lymphoid organs; function; development; development function ... See more keywords
Secondary Lymphoid Organs in Mesenchymal Stromal Cell Therapy: More Than Just a Filter
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.892443
Abstract: Mesenchymal stromal cells (MSCs) have demonstrated therapeutic potential in inflammatory models of human disease. However, clinical translation has fallen short of expectations, with many trials failing to meet primary endpoints. Failure to fully understand their… read more here.
Keywords: mesenchymal stromal; organs mesenchymal; secondary lymphoid; stromal cell ... See more keywords