Tertiary lymphoid structures in head and neck squamous cell carcinoma improve prognosis by recruiting CD8+ T cells.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13403
Abstract: Tertiary lymphoid structures (TLSs) are formed in long-term chronic inflammation, promoting the local recruitment of lymphocytes, antigen presentation, and regulation of immune response, correlated with a better prognosis for cancer patients. Although studies have been… read more here.
Keywords: cell; prognosis; lymphoid structures; cd8 cells ... See more keywords
Tertiary lymphoid structures in lung adenocarcinoma: characteristics and related factors
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.4796
Abstract: Tertiary lymphoid structures (TLSs) are found in a variety of malignancies and affect the growth of tumors, but few studies have addressed their role in lung adenocarcinoma (LAC). We aimed to evaluate clinical features associated… read more here.
Keywords: lung adenocarcinoma; lymphoid structures; adenocarcinoma characteristics; characteristics related ... See more keywords
Multiplex Immunofluorescence Histology for Immune Cell Infiltrates in Melanoma-Associated Tertiary Lymphoid Structures.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1205-7_40
Abstract: The presence of tertiary lymphoid structures (TLS) is correlated with prolonged patient survival in a variety of solid cancers, including melanoma. However, few methods have been described that could enable a more comprehensive understanding of… read more here.
Keywords: immune; infiltrates melanoma; multiplex immunofluorescence; lymphoid structures ... See more keywords
A Quantitative Pathology Approach to Analyze the Development of Human Cancer-Associated Tertiary Lymphoid Structures.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8709-2_5
Abstract: Tertiary lymphoid structures (TLS) develop in the human tumor microenvironment and correlate with prolonged survival in most cancer types. We recently demonstrated that TLS development follows sequential maturation stages and culminates in the generation of… read more here.
Keywords: quantitative pathology; pathology; lymphoid structures; cancer ... See more keywords
Presence of tertiary lymphoid structures determines the level of tumor-infiltrating lymphocytes in primary breast cancer and metastasis
Sign Up to like & getrecommendations! Published in 2018 at "Modern Pathology"
DOI: 10.1038/s41379-018-0113-8
Abstract: The level of tumor-infiltrating lymphocytes and presence of tertiary lymphoid structures are significant prognostic and predictive factors in primary breast cancer. However, the understanding about differences in tumor-infiltrating lymphocytes and tertiary lymphoid structures at various… read more here.
Keywords: infiltrating lymphocytes; tumor infiltrating; lymphoid structures; tertiary lymphoid ... See more keywords
Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures.
Sign Up to like & getrecommendations! Published in 2022 at "Nature communications"
DOI: 10.1038/s41467-022-29701-x
Abstract: Tertiary lymphoid structures (TLS) are lymph node-like immune cell clusters that emerge during chronic inflammation in non-lymphoid organs like the kidney, but their origin remains not well understood. Here we show, using conditional deletion strategies… read more here.
Keywords: formation; lymphoid structures; loss; notch signaling ... See more keywords
Tertiary Lymphoid Structures, Immune Response, and Prognostic Relevance in Non-Small Cell Lung Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Investigation"
DOI: 10.1080/07357907.2022.2136684
Abstract: Abstract We assessed the presence of ‘tertiary lymphoid structures’ (TLS) in a series of surgically treated non-small cell lung carcinomas (NSCLC). The TLS-density in the tumor periphery (pTLS) ranged from 0 to 1.8 (median 0.45),… read more here.
Keywords: non small; lymphoid structures; small cell; tertiary lymphoid ... See more keywords
Tertiary lymphoid structures and their association to immune phenotypes and circulatory IL2 levels in pancreatic ductal adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Oncoimmunology"
DOI: 10.1080/2162402x.2022.2027148
Abstract: ABSTRACT Pancreatic ductal adenocarcinoma (PDA) is usually unresponsive to immunotherapeutic approaches. However, tertiary lymphoid structures (TLS) are associated with favorable patient outcomes in PDA. A better understanding of the B cell infiltrate and biological features… read more here.
Keywords: lymphoid structures; il2 levels; circulatory il2; ductal adenocarcinoma ... See more keywords
Extracellular vesicles derived from injured vascular tissue promote the formation of tertiary lymphoid structures in vascular allografts
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Transplantation"
DOI: 10.1111/ajt.15707
Abstract: Tertiary lymphoid structures (TLS) accumulate at sites of chronic injury where they function as an ectopic germinal center, fostering local autoimmune responses. Vascular injury leads to the release of endothelial‐derived apoptotic exosome‐like vesicles (ApoExo) that… read more here.
Keywords: extracellular vesicles; formation; lymphoid structures; tertiary lymphoid ... See more keywords
Tertiary lymphoid structures in breast ductal carcinoma in situ correlate with adverse pathological parameters
Sign Up to like & getrecommendations! Published in 2023 at "Histopathology"
DOI: 10.1111/his.14865
Abstract: To investigate tertiary lymphoid structures (TLSs) in ductal carcinoma in situ (DCIS) of the breast and their correlation with pathological features, immune cell markers and clinical outcomes. read more here.
Keywords: lymphoid structures; ductal carcinoma; carcinoma situ; tertiary lymphoid ... See more keywords
Stromal cells in tertiary lymphoid structures: Architects of autoimmunity
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DOI: 10.1111/imr.12987
Abstract: The molecular mediators present within the inflammatory microenvironment are able, in certain conditions, to favor the initiation of tertiary lymphoid structure (TLS) development. TLS is organized lymphocyte clusters able to support antigen‐specific immune response in… read more here.
Keywords: cells tertiary; architects autoimmunity; structures architects; stromal cells ... See more keywords