Nimbolide retards T cell lymphoma progression by altering apoptosis, glucose metabolism, pH regulation, and ROS homeostasis.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental toxicology"
DOI: 10.1002/tox.23497
Abstract: Nimbolide is reported as one of the potential anticancer candidates of the neem tree (Azadirachta indica A. Juss). The cytotoxic action of nimbolide has been well reported against a wide number of malignancies, including breast,… read more here.
Keywords: apoptosis; lymphoma progression; homeostasis; cell lymphoma ... See more keywords
Therapeutic targeting miR130b counteracts diffuse large B-cell lymphoma progression via OX40/OX40L-mediated interaction with Th17 cells
Sign Up to like & getrecommendations! Published in 2022 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-022-00895-2
Abstract: MicroRNAs (miRNAs) are involved in lymphoma progression by regulating the tumor microenvironment. Serum miR130b is overexpressed in diffuse large B-cell lymphoma (DLBCL), inducing Th17 cell alterations. To further illustrate its biological significance and therapeutic rationale,… read more here.
Keywords: mir130b; lymphoma progression; th17 cells; cell ... See more keywords
Outcomes and management of patients with mantle cell lymphoma after progression on brexucabtagene autoleucel therapy
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Haematology"
DOI: 10.1111/bjh.17197
Abstract: yet to recover to the pre-COVID-19 levels. Maintaining capacity to treat patients with high-risk haematological malignancies is essential requiring adherence to guidelines designed to reduce the spread of infection and create a safe environment for… read more here.
Keywords: cell lymphoma; outcomes management; patients mantle; mantle cell ... See more keywords
Abstract 2226: Modeling the role of Tet-deficiency and restoration in Bcl2-driven B cell lymphoma progression
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-2226
Abstract: Loss of function in DNA methylation regulators such as the Ten-eleven translocation (TET1-3) proteins, have been implicated in the progression of lymphoma. TET enzymes constitute a family of iron and αKG-dependent dioxygenases that oxidize 5-methylcytosine… read more here.
Keywords: lymphoma progression; tet deficiency; cell lymphoma; progression ... See more keywords
Proinflammatory microenvironment promotes lymphoma progression in mice with high megakaryocyte and TPO levels
Sign Up to like & getrecommendations! Published in 2022 at "Blood Advances"
DOI: 10.1182/bloodadvances.2022007849
Abstract: Key Points • Increased levels of interleukin 1 were found in the bone marrow fluid of TpoTg mice, whereas levels were lowered in Mpl−/− mice.• A proinflammatory microenvironment promoted Eμ-myc lymphoma progression in TpoTg mice… read more here.
Keywords: proinflammatory microenvironment; lymphoma progression; high megakaryocyte; mice high ... See more keywords