Loss of Setd4 delays radiation-induced thymic lymphoma in mice.
Sign Up to like & getrecommendations! Published in 2019 at "DNA repair"
DOI: 10.1016/j.dnarep.2019.102754
Abstract: Radiation-induced lymphomagenesis results from a clonogenic lymphoid cell proliferation due to genetic alterations and immunological dysregulation. Mouse models had been successfully used to identify risk and protective factors for radiation-induced DNA damage and carcinogenesis. The… read more here.
Keywords: setd4; lymphoma; radiation induced; lymphomagenesis ... See more keywords
Loss of CREBBP and KMT2D cooperate to accelerate lymphomagenesis and shape the lymphoma immune microenvironment
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DOI: 10.1038/s41467-024-47012-1
Abstract: Despite regulating overlapping gene enhancers and pathways, CREBBP and KMT2D mutations recurrently co-occur in germinal center (GC) B cell-derived lymphomas, suggesting potential oncogenic cooperation. Herein, we report that combined haploinsufficiency of Crebbp and Kmt2d induces… read more here.
Keywords: crebbp kmt2d; crebbp; cell; lymphomagenesis ... See more keywords
The X-linked helicase DDX3X is required for lymphoid differentiation and MYC-driven lymphomagenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-21-2454
Abstract: The X-linked gene DDX3X encodes an RNA helicase that is mutated at high frequencies in several types of human B-cell lymphoma. Females have two active DDX3X alleles and males carry a DDX3Y homolog on the… read more here.
Keywords: lymphomagenesis; driven lymphomagenesis; helicase ddx3x; ddx3x ... See more keywords
Abstract 1404: Blood-based transcriptomics provides novel insights into Sjögren's syndrome-associated lymphomagenesis
Sign Up to like & getrecommendations! Published in 2024 at "Cancer Research"
DOI: 10.1158/1538-7445.am2024-1404
Abstract: Sjögren's syndrome (SS) is a debilitating autoimmune disorder that carries the highest risk of progressing to lymphoma among all autoimmune diseases, with up to 10% of patients developing SS-associated lymphoma. However, the underlying mechanisms are… read more here.
Keywords: blood based; gren syndrome; cell; lymphomagenesis ... See more keywords
PARK2 Regulates eIF4B-Driven Lymphomagenesis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Cancer Research"
DOI: 10.1158/1541-7786.mcr-21-0729
Abstract: Abstract Patients with high-risk diffuse large B-cell lymphoma have poor outcomes following first-line cyclophosphamide, doxorubicin, vincristine, prednisone, and rituximab (R-CHOP); thus, treatment of this fatal disease remains an area of unmet medical need and requires… read more here.
Keywords: park2 regulates; lymphomagenesis; protein translation; park2 ... See more keywords
SETD2 haploinsufficiency enhances germinal center-associated AICDA somatic hypermutation to drive B cell lymphomagenesis.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-21-1514
Abstract: SETD2 is the sole histone methyltransferase responsible for H3K36me3, with roles in splicing, transcription initiation and DNA damage response. Homozygous disruption of SETD2 yields a tumor suppressor effect in various cancers. However, SETD2 mutation is… read more here.
Keywords: lymphomagenesis; dna damage; somatic hypermutation; setd2 haploinsufficiency ... See more keywords
Generation of faithful autochthonous mouse models of Mantle Cell Lymphoma
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DOI: 10.1182/blood-2025-1757
Abstract: Introduction: MantleCell Lymphoma (MCL) is characterized by the translocation t(11;14) resulting in overexpression of Cyclin D1. Other frequently observed alterations include SOX11 overexpression (90% of patients), and aberrations of ATM (42-56%) and TP53 (16-31%). Despite… read more here.
Keywords: mcl; cell; mcl like; lymphomagenesis ... See more keywords
Calorie restriction alters the mechanisms of radiation-induced mouse thymic lymphomagenesis
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DOI: 10.1371/journal.pone.0280560
Abstract: Calorie restriction (CR) suppresses not only spontaneous but also chemical- and radiation-induced carcinogenesis. Our previous study revealed that the cancer-preventive effect of CR is tissue dependent and that CR does not effectively prevent the development… read more here.
Keywords: calorie restriction; lymphomagenesis; group; radiation ... See more keywords