Acute severe lymphopenia by radiotherapy is associated with reduced overall survival in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Strahlentherapie und Onkologie"
DOI: 10.1007/s00066-019-01462-5
Abstract: PurposeRadiotherapy (RT) for peripheral organs can affect circulating lymphocytes and cause lymphopenia. We aimed to investigate RT-related lymphopenia in patients with hepatocellular carcinoma (HCC).MethodsMedical records of 920 patients who received RT for HCC during 2001–2016… read more here.
Keywords: lymphopenia; der; severe lymphopenia; mit ... See more keywords
Real-world comparison of lymphopenia profiles in S1P receptor modulators for multiple sclerosis: a multicenter retrospective study
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DOI: 10.1007/s00415-025-13300-z
Abstract: Sphingosine-1-phosphate (S1P) receptor modulators, regulating the S1P/S1PR pathway, lead to lymphocyte sequestration in lymphoid organs, which results in peripheral lymphopenia. This study evaluates the degree of lymphopenia induced by S1P modulators in people with Multiple… read more here.
Keywords: s1p receptor; lymphopenia; siponimod; receptor modulators ... See more keywords
Lymphopenia after induction chemotherapy correlates with incomplete surgical resection in patients with advanced ovarian cancer
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DOI: 10.1007/s10147-018-1374-4
Abstract: BackgroundLymphopenia is associated with poor outcomes in patients with various cancers, but little is known about the prognostic impact of lymphopenia in patients with epithelial ovarian cancer (EOC) after induction chemotherapy (IC). This study investigated… read more here.
Keywords: resection; lymphopenia; ovarian cancer; patients advanced ... See more keywords
Lymphopenia associated with sphingosine 1-phosphate receptor modulators (S1PRMs) in multiple sclerosis: analysis of European pharmacovigilance data
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DOI: 10.1007/s43440-025-00725-6
Abstract: The treatment landscape for Multiple Sclerosis (MS) has increased significantly over the past few decades, thanks to the introduction of disease-modifying therapies (DMTs). Fingolimod, siponimod, ozanimod, and ponesimod belong to the newer generation of oral… read more here.
Keywords: multiple sclerosis; lymphopenia; sphingosine phosphate; modulators s1prms ... See more keywords
Early predictive risk factors for dimethyl fumarate-associated lymphopenia in patients with multiple sclerosis.
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DOI: 10.1016/j.msard.2022.103669
Abstract: BACKGROUND Lymphopenia is a major concern in MS patients treated with dimethyl-fumarate (DMF) as it increases the risk of progressive multifocal leukoencephalopathy. A pronounced reduction in absolute lymphocyte counts (ALCs) early after treatment initiation has… read more here.
Keywords: risk; dimethyl fumarate; predictive risk; alcs ... See more keywords
Extremely severe CD4 lymphopenia during HIV-1 primary infection.
Sign Up to like & getrecommendations! Published in 2019 at "AIDS research and human retroviruses"
DOI: 10.1089/aid.2019.0065
Abstract: We report the case of a patient with a very profound CD4-T cell lymphopenia below 20 cells/mm3 in the context of a primary HIV-1 infection, associated with both delayed HIV-specific antibody and CD8-T cell responses.… read more here.
Keywords: hiv; lymphopenia; infection; cd4 ... See more keywords
CTIM-23. FIRST-IN-HUMAN IMMUNOTHERAPY TARGETING LYMPHOPENIA IN RECURRENT GLIOBLASTOMA MULTIFORM (GBM): NAI AND PD-L1 T-HANK PLUS BEVACIZUMAB WITH COMPLETE RESPONSE
Sign Up to like & getrecommendations! Published in 2025 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noaf201.0480
Abstract: Treatment options for recurrent GBM are limited and associated with high mortality. We hypothesize that current standards of care for GBM induce severe lymphopenia, and by treating lymphopenia (activating NK & T-cells, lymphocytes key to… read more here.
Keywords: lymphopenia; immunotherapy; complete response; gbm ... See more keywords
Efficiency of nicotinamide-based supportive therapy in lymphopenia for patients with ordinary or severe COVID-19: A randomized controlled trial
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DOI: 10.1097/md.0000000000031138
Abstract: Background: This study aimed to investigate the efficiency of nicotinamide-based supportive therapy for lymphopenia in patients with coronavirus disease-2019 (COVID-19). Methods: Twenty four patients diagnosed with COVID-19 were randomly divided into 2 groups (n =… read more here.
Keywords: lymphopenia; therapy; covid; nicotinamide based ... See more keywords
High prevalence of peripheral lymphopenia in Langerhans cell histiocytosis
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DOI: 10.1111/bjh.16923
Abstract: In the inflammatory myeloid neoplasia called Langerhans cell histiocytosis (LCH), leukocytes accumulate in tissues causing granulomatous lesions. The disease ranges from mild (singlesystem, SS) to severe (multisystem, MS) manifestations with potential involvement of risk organs… read more here.
Keywords: lymphopenia; diagnosis; treatment; prevalence ... See more keywords
CD4+ T cell lymphopenia predicts mortality from Pneumocystis pneumonia in kidney transplant patients
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DOI: 10.1111/ctr.13877
Abstract: Pneumocystis jirovecii pneumonia (PcP) remains a life‐threatening opportunistic infection after solid organ transplantation, even in the era of Pneumocystis prophylaxis. The association between risk of developing PcP and low CD4+ T cell counts has been… read more here.
Keywords: lymphopenia; pneumocystis; transplant; cd4 cell ... See more keywords
Lymphopenia in sepsis-an acquired immunodeficiency?
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DOI: 10.1111/imcb.12611
Abstract: Sepsis is a global health priority, yet effective host-directed targeted therapies have not been identified outside of the setting of COVID-19. Lymphopenia occurs in up to ~52% of patients with sepsis and is associated with… read more here.
Keywords: sepsis; lymphopenia; acquired immunodeficiency; sepsis acquired ... See more keywords