RECONSTITUTION OF T LYMPHOPOIESIS FROM PLURIPOTENT STEM CELLS BY DEFINED TRANSCRIPTION FACTORS
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.06.316
Abstract: Pluripotent stem cells (PSC)-generated induced PTP could only reconstitute functional T lymphopoiesis in vivo when pre-embedded in congenic fetal thymic lobes, indicative of a cell-intrinsic flaw of homing capacity in vivo.In this study, we identified… read more here.
Keywords: stem cells; vivo; lymphopoiesis; transcription factors ... See more keywords
Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.09.23.509256
Abstract: Acute lymphoblastic and myeloblastic leukemias (ALL and AML) have been known to modify the bone marrow microenvironment and disrupt non-malignant hematopoiesis. However, the molecular mechanisms driving these alterations remain poorly defined. Here we show that… read more here.
Keywords: lymphotoxin; mesenchymal stem; lymphopoiesis; stem cells ... See more keywords