Efficacy and safety of recombinant human lymphotoxin‐α derivative with cisplatin and fluorouracil in patients with metastatic esophageal squamous cell carcinoma: A randomized, multicenter, open‐label, controlled, phase 2b trial
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DOI: 10.1002/cncr.30845
Abstract: Recombinant human lymphotoxin‐α derivative (rhLTα‐Da) is a lymphotoxin‐α derivative that is missing 27 N‐terminal amino acid residues. Previous studies indicated a benefit from the addition of rhLTα‐Da to cisplatin‐based treatment in patients with metastatic esophageal… read more here.
Keywords: recombinant human; lymphotoxin; metastatic esophageal; patients metastatic ... See more keywords
Metabolic activation and colitis pathogenesis is prevented by lymphotoxin β receptor expression in neutrophils
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DOI: 10.1038/s41385-021-00378-7
Abstract: Inflammatory bowel disease is characterized by an exacerbated intestinal immune response, but the critical mechanisms regulating immune activation remain incompletely understood. We previously reported that the TNF-superfamily molecule TNFSF14 (LIGHT) is required for preventing severe… read more here.
Keywords: metabolic activation; lymphotoxin; colitis; activation ... See more keywords
Cell circuits between leukemic cells and mesenchymal stem cells block lymphopoiesis by activating lymphotoxin beta receptor signaling
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DOI: 10.1101/2022.09.23.509256
Abstract: Acute lymphoblastic and myeloblastic leukemias (ALL and AML) have been known to modify the bone marrow microenvironment and disrupt non-malignant hematopoiesis. However, the molecular mechanisms driving these alterations remain poorly defined. Here we show that… read more here.
Keywords: lymphotoxin; mesenchymal stem; lymphopoiesis; stem cells ... See more keywords
Hepatitis B virus covalently closed circular DNA homeostasis is independent of the lymphotoxin pathway during chronic HBV infection
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DOI: 10.1111/jvh.12689
Abstract: Current treatment options for patients with chronic hepatitis B virus (HBV) infection are not curative as they are not effective in eliminating covalently closed circular DNA (cccDNA). cccDNA is a stable template for HBV transcription… read more here.
Keywords: cccdna; lymphotoxin; hbv; lymphotoxin pathway ... See more keywords
Human Papillomavirus 16 E6 Suppresses Transporter Associated with Antigen-Processing Complex in Human Tongue Keratinocyte Cells by Activating Lymphotoxin Pathway
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DOI: 10.3390/cancers14081944
Abstract: Simple Summary There is still limited knowledge of the critical pathogenic processes by which HPV16 induces oral carcinogenesis. Therefore, we aimed to illuminate the oncogenic role of HPV16 in the context of oral squamous cell… read more here.
Keywords: transporter associated; processing complex; antigen processing; lymphotoxin ... See more keywords