Tetraspanin CD53 modulates lymphocyte trafficking but not systemic autoimmunity in Lyn-deficient mice.
Sign Up to like & getrecommendations! Published in 2021 at "Immunology and cell biology"
DOI: 10.1111/imcb.12501
Abstract: The leukocyte-restricted tetraspanin CD53 has been shown to promote lymphocyte homing to lymph nodes and myeloid cell recruitment to acutely inflamed peripheral organs, and accelerate the onset of immune-mediated disease. However, its contribution in the… read more here.
Keywords: systemic autoimmunity; lyn; mice; tetraspanin cd53 ... See more keywords
A phospho-tyrosine–based signaling module using SPOP, CSK, and LYN controls TLR-induced IRF activity
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abq0084
Abstract: Toll-like receptors (TLRs) recognize pathogen- and host-derived factors and control immune responses via the adaptor protein MyD88 and members of the interferon regulatory transcription factor (IRF) family. IRFs orchestrate key effector functions, including cytokine release,… read more here.
Keywords: csk; tlr induced; activity; spop csk ... See more keywords
Abstract 4372: SET/PP2A/SHP-1/Lyn oncogenic signaling contributes to tumor aggressiveness in diffuse large B cell lymphoma
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4372
Abstract: Purpose: Diffuse large B-cell lymphoma (DLBCL) is aggressive non-Hodgkin lymphoma. It is a heterogeneous disease and is classified as germinal center B-cell like (GCB) and activated B-cell like (ABC) subtypes according to gene-expression profiling. The… read more here.
Keywords: shp lyn; pp2a shp; lyn; cell ... See more keywords
MicroRNA-218-5p inhibits cell growth and metastasis in cervical cancer via LYN/NF-κB signaling pathway
Sign Up to like & getrecommendations! Published in 2018 at "Cancer Cell International"
DOI: 10.1186/s12935-018-0673-1
Abstract: BackgroundWe are committed to investigate miR-218-5 effects on the progression of cervical cancer (CC) cell and find out the molecular mechanism.MethodsGSE9750 was obtained from GEO database and R Limma package was applied to filter out… read more here.
Keywords: via lyn; mir 218; cervical cancer; lyn ... See more keywords
Minocycline binds and inhibits LYN activity to prevent STAT3-meditated metastasis of colorectal cancer
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Biological Sciences"
DOI: 10.7150/ijbs.70708
Abstract: Colorectal cancer (CRC) is one of the most common malignancies worldwide. Metastasis is a major cause of CRC recurrence and mortality. Several antibiotic drugs have been reported to exert potential anticancer activities, however, whether and… read more here.
Keywords: metastasis; stat3; crc; cancer ... See more keywords