FRI0269 Deficiency of glucocorticoid-induced leucine zipper (GILZ) disinhibits ifn pathways and exacerbates nephritis in the lyn-deficient murine model of lupus
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DOI: 10.1136/annrheumdis-2018-eular.4094
Abstract: Background Systemic lupus erythematosus (SLE) is a multi-system autoimmune disease of unknown etiology. Lyn-deficient mice develop lupus-like autoimmunity due to hyperactive B cells resulting in excess IL-6 production, and cyclical exacerbation of inflammation by further… read more here.
Keywords: lyn deficient; glucocorticoid induced; gilz; mice ... See more keywords