Conditional CRISPR‐mediated deletion of Lyn kinase enhances differentiation and function of iPSC‐derived megakaryocytes
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Thrombosis and Haemostasis"
DOI: 10.1111/jth.15546
Abstract: Thrombocytopenia leading to life‐threatening excessive bleeding can be treated by platelet transfusion. Currently, such treatments are totally dependent on donor‐derived platelets. To support future applications in the use of in vitro‐derived platelets, we sought to… read more here.
Keywords: conditional crispr; crispr mediated; deletion lyn; lyn kinase ... See more keywords
Targeting Lyn Kinase in Chorea-Acanthocytosis: A Translational Treatment Approach in a Rare Disease
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm11050392
Abstract: Background: Chorea-acanthocytosis (ChAc) is a neurodegenerative disease caused by mutations in the VPS13A gene. It is characterized by several neurological symptoms and the appearance of acanthocytes. Elevated tyrosine kinase Lyn activity has been recently identified… read more here.
Keywords: chorea acanthocytosis; lyn kinase; kinase; disease ... See more keywords