Lynch‐like syndrome is as frequent as Lynch syndrome in early‐onset nonfamilial nonpolyposis colorectal cancer
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DOI: 10.1002/ijc.32160
Abstract: Early‐onset ( read more here.
Keywords: early onset; lynch; colorectal cancer; lynch like ... See more keywords
Overcoming the challenges associated with universal screening for Lynch syndrome in colorectal and endometrial cancer
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DOI: 10.1038/s41436-020-0819-0
Abstract: Cancer genetics is moving toward widespread testing for genetic susceptibility to cancer, for example in breast and ovarian cancer patients. Regarding colorectal and endometrial cancer (CRC, EC), guidelines now recommend universal screening for Lynch syndrome… read more here.
Keywords: genetics; mlh1 hyper; lynch like; cancer ... See more keywords
Universal Screening for Mismatch-Repair Deficiency in Endometrial Cancers to Identify Patients With Lynch Syndrome and Lynch-like Syndrome
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DOI: 10.1097/pgp.0000000000000312
Abstract: Although consensus has yet to be reached on universal mismatch-repair (MMR) protein immunohistochemical (IHC) screening for Lynch syndrome (LS) in endometrial cancer (EC), an increasing number of institutions have adopted universal screening protocols similar to… read more here.
Keywords: universal screening; lynch like; mismatch repair; lynch syndrome ... See more keywords
Comprehensive Constitutional Genetic and Epigenetic Characterization of Lynch-Like Individuals
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DOI: 10.3390/cancers12071799
Abstract: The causal mechanism for cancer predisposition in Lynch-like syndrome (LLS) remains unknown. Our aim was to elucidate the constitutional basis of mismatch repair (MMR) deficiency in LLS patients throughout a comprehensive (epi)genetic analysis. One hundred… read more here.
Keywords: analysis; constitutional genetic; lynch like; comprehensive constitutional ... See more keywords
Risk of Cancer in Family Members of Patients with Lynch-Like Syndrome
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DOI: 10.3390/cancers12082225
Abstract: Lynch syndrome (LS) is a common cause of hereditary colorectal cancer (CRC). Some CRC patients develop mismatch repair deficiency without germline pathogenic mutation, known as Lynch-like syndrome (LLS). We compared the risk of CRC in… read more here.
Keywords: risk; lynch like; crc; cancer ... See more keywords
Lynch-like Syndrome: Potential Mechanisms and Management
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DOI: 10.3390/cancers14051115
Abstract: Simple Summary Lynch-like syndrome (LLS) is defined as colorectal cancer cases with microsatellite instability (MSI) and loss of expression of MLH1, MSH2, MSH6, or PMS2 by immunohistochemistry (IHC) in the absence of a germline mutation… read more here.
Keywords: like syndrome; lynch syndrome; sporadic cases; lynch like ... See more keywords
Whole-Exome Sequencing Identifies Pathogenic Germline Variants in Patients with Lynch-Like Syndrome
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DOI: 10.3390/cancers14174233
Abstract: Simple Summary A significant proportion of families with a clinical suggestion of Lynch syndrome and screened for the known MMR genes remain without a molecular diagnosis. These patients, who generally show a suggestive family pedigree… read more here.
Keywords: like syndrome; lynch like; germline variants; whole exome ... See more keywords