Deletion of lynx1 reduces the function of α6* nicotinic receptors
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DOI: 10.1371/journal.pone.0188715
Abstract: The α6 nicotinic acetylcholine receptor (nAChR) subunit is an attractive drug target for treating nicotine addiction because it is present at limited sites in the brain including the reward pathway. Lynx1 modulates several nAChR subtypes;… read more here.
Keywords: nicotine; deletion lynx1; function; lynx1 removal ... See more keywords
Expression and Roles of Lynx1, a Modulator of Cholinergic Transmission, in Skeletal Muscles and Neuromuscular Junctions in Mice
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DOI: 10.3389/fcell.2022.838612
Abstract: Lynx1 is a glycosylphosphatidylinositol (GPI)-linked protein shown to affect synaptic plasticity through modulation of nicotinic acetylcholine receptor (nAChR) subtypes in the brain. Because of this function and structural similarity to α-bungarotoxin, which binds muscle-specific nAChRs… read more here.
Keywords: muscles neuromuscular; expression roles; lynx1; neuromuscular junctions ... See more keywords
From Synthetic Fragments of Endogenous Three-Finger Proteins to Potential Drugs
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DOI: 10.3389/fphar.2019.00748
Abstract: The proteins of the Ly6 family have a three-finger folding as snake venom α-neurotoxins, targeting nicotinic acetylcholine receptors (nAChRs), and some of them, like mammalian secreted Ly6/uPAR protein (SLURP1) and membrane-attached Ly-6/neurotoxin (Lynx1), also interact… read more here.
Keywords: synthetic fragments; three finger; endogenous three; fragments endogenous ... See more keywords