Lyophilization of Synthetic Gene Carriers.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9092-4_14
Abstract: Lyophilization, also known as freeze drying, is a widely used method for stabilization, improvement of long-term storage stability, and simplification of handling of drugs and/or carrier systems. Lyophilization is time-consuming and energy-consuming, and hence optimized… read more here.
Keywords: stability; lyophilization synthetic; lyophilization; gene carriers ... See more keywords
Lyophilized liposome-based parenteral drug development: Reviewing complex product design strategies and current regulatory environments.
Sign Up to like & getrecommendations! Published in 2019 at "Advanced drug delivery reviews"
DOI: 10.1016/j.addr.2019.03.003
Abstract: Given the successful entry of several liposomal drug products into market, and some with decades of clinical efficacy, liposomal drug delivery systems have proven capabilities to overcome certain limitations of traditional drug delivery, especially for… read more here.
Keywords: product; lyophilized liposome; drug; lyophilization ... See more keywords
Effects of lyophilization on colorimetric indices, phenolics content, and antioxidant activity of avocado (Persea americana) pulp
Sign Up to like & getrecommendations! Published in 2022 at "Food Control"
DOI: 10.1016/j.foodcont.2021.108526
Abstract: Abstract Drying processes can be performed using different methods, with the selected technique and operational conditions directly influencing the quality of the final product. The aim of this work was to evaluate the effect of… read more here.
Keywords: antioxidant activity; lyophilization; temperature; colorimetric indices ... See more keywords
Unexplored benefits of controlled ice nucleation: Lyophilization of a highly concentrated monoclonal antibody solution
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Pharmaceutics"
DOI: 10.1016/j.ijpharm.2018.09.057
Abstract: ABSTRACT The study explores new benefits of controlled ice nucleation during lyophilization. A highly concentrated monoclonal antibody product was lyophilized using conventional (uncontrolled) and controlled ice nucleation freezing and the processes were compared for their… read more here.
Keywords: ice nucleation; benefits controlled; nucleation; lyophilization ... See more keywords
Excipients for the lyoprotection of MAPKAP kinase 2 inhibitory peptide nano‐polyplexes
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Controlled Release"
DOI: 10.1016/j.jconrel.2018.04.045
Abstract: ABSTRACT Herein, excipients are investigated to ameliorate the deleterious effects of lyophilization on peptide‐polymer nano‐polyplex (NP) morphology, cellular uptake, and bioactivity. The NPs are a previously‐described platform technology for intracellular peptide delivery and are formulated… read more here.
Keywords: post lyophilization; nps lyophilized; kinase inhibitory; lyophilization ... See more keywords
Microencapsulation of Lactobacillus casei BNCC 134415 under lyophilization enhances cell viability during cold storage and pasteurization, and in simulated gastrointestinal fluids
Sign Up to like & getrecommendations! Published in 2019 at "Lwt - Food Science and Technology"
DOI: 10.1016/j.lwt.2019.108521
Abstract: Abstract Lactobacillus casei BNCC 134415 cells were micro-encapsulated in whey protein isolate (WPI), WPI + Gellan gum (GG), WPI+ cellulose acetate phthalate (CAP) or WPI+GG+CAP as capsule matrixes under lyophilization. Physical and chemical properties of the microcapsules and viability… read more here.
Keywords: simulated gastrointestinal; lyophilization; casei bncc; viability ... See more keywords
Crystallization of Cyclophosphamide Monohydrate During Lyophilization.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmaceutical sciences"
DOI: 10.1016/j.xphs.2018.10.020
Abstract: The purpose of this study was to investigate the phase behavior of cyclophosphamide (CPA) during various stages of lyophilization, with special emphasis on obtaining crystalline CPA monohydrate (CPA-MH) in the lyophilized product. Subambient differential scanning… read more here.
Keywords: monohydrate; lyophilization; cpa; crystallization cyclophosphamide ... See more keywords
Optimizing Formulation and Lyophilization Process for a Fragment Antigen Binding (Fab) Protein Using Solid-state Hydrogen Deuterium Exchange Mass Spectrometry (ssHDX-MS).
Sign Up to like & getrecommendations! Published in 2019 at "Molecular pharmaceutics"
DOI: 10.1021/acs.molpharmaceut.9b00614
Abstract: PURPOSE Solid-state hydrogen deuterium exchange with mass spectrometry (ssHDX-MS) was evaluated as an analytical method to rapidly screen and select an optimal lyophilized fragment antigen binding protein (Fab) formulation and the optimal lyophilization cycle. METHODOLOGY… read more here.
Keywords: solid state; lyophilization; state; deuterium incorporation ... See more keywords
High-Performance Three-Dimensional Mesoporous Graphene Electrode for Supercapacitors using Lyophilization and Plasma Reduction.
Sign Up to like & getrecommendations! Published in 2017 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.6b13050
Abstract: In this study, a three-dimensional (3D) mesoporous plasma-reduced graphene oxide web (mPrGO web) was fabricated via lyophilization of graphene oxide (GO) solution and subsequent plasma reduction. The lyophilized graphene oxide web (GO web) was successfully… read more here.
Keywords: reduction; plasma; plasma reduction; lyophilization ... See more keywords
Preservation by lyophilization of a human intestinal microbiota: influence of the cultivation pH on the drying outcome and re‐establishment ability
Sign Up to like & getrecommendations! Published in 2022 at "Microbial Biotechnology"
DOI: 10.1111/1751-7915.14007
Abstract: Faecal microbiota transplantation is an emerging medical concept for the treatment of gastrointestinal diseases. This concept, however, has disadvantages as low storability of stool and intensive donor screening. A solution to overcome these problems would… read more here.
Keywords: lyophilization; microbiota; cultivation; cultivation drying ... See more keywords
Effect of lyophilization on HRP–antibody conjugation: an enhanced antibody labeling technology
Sign Up to like & getrecommendations! Published in 2018 at "BMC Research Notes"
DOI: 10.1186/s13104-018-3688-8
Abstract: ObjectiveImmunoassay usually deal with the antibody labeling with various reporter molecules, one such useful reporter molecule is horseradish peroxidase (HRPO). Conjugating enzyme with antibody without losing its enzymatic activity is a challenging task. Our aim… read more here.
Keywords: antibody labeling; antibody; hrp antibody; lyophilization ... See more keywords