Loss of Lypd6 leads to reduced anxiety-like behaviour and enhanced responses to nicotine
Sign Up to like & getrecommendations! Published in 2018 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2017.11.025
Abstract: &NA; Nicotine consumption through smoking affects anxious states in humans. However, the precise role of nicotinic acetylcholine receptor (nAChR) circuitry in the regulation of anxiety remains elusive. The Lynx protein Lypd6 is highly enriched in… read more here.
Keywords: anxiety; loss lypd6; anxiety like; lypd6 leads ... See more keywords
Human Three-Finger Protein Lypd6 Is a Negative Modulator of the Cholinergic System in the Brain
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.662227
Abstract: Lypd6 is a GPI-tethered protein from the Ly-6/uPAR family expressed in the brain. Lypd6 enhances the Wnt/β-catenin signaling, although its action on nicotinic acetylcholine receptors (nAChRs) have been also proposed. To investigate a cholinergic activity… read more here.
Keywords: negative modulator; protein lypd6; brain; three finger ... See more keywords