Production of interferon-gamma, interleukin-6, and interleukin-1β by human peripheral blood mononuclear cells stimulated with novel lys-gingipain synthetic peptides.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of periodontology"
DOI: 10.1002/jper.18-0626
Abstract: BACKGROUND Periodontitis is a progressive inflammatory process, and its pathogenesis is related to the presence of a dysbiotic subgingival biofilm that elicits the immune response. Porphyromonas gingivalis is a keystone pathogen, and its Lys-gingipain (Kgp)… read more here.
Keywords: peripheral blood; lys gingipain; production; synthetic peptides ... See more keywords
Porphyromonas gingivalis laboratory strains and clinical isolates exhibit different distribution of cell surface and secreted gingipains
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Oral Microbiology"
DOI: 10.1080/20002297.2020.1858001
Abstract: ABSTRACT Background: The cell-surface cysteine proteinases RgpA, RgpB (Arg-gingipain), and Kgp (Lys-gingipain) are major virulence factors of P. gingivalis, a keystone pathogen in the development of destructive periodontal disease. The gingipains function as proteinases and… read more here.
Keywords: cell surface; lys gingipain; clinical isolates; gingipain ... See more keywords