Lysosomal enzyme trafficking factor LYSET enables nutritional usage of extracellular proteins
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DOI: 10.1126/science.abn5637
Abstract: Mammalian cells can generate amino acids through macropinocytosis and lysosomal breakdown of extracellular proteins, which is exploited by cancer cells to grow in nutrient-poor tumors. Through genetic screens in defined nutrient conditions, we characterized LYSET,… read more here.
Keywords: amino acids; glcnac phosphotransferase; extracellular proteins; cancer ... See more keywords
The human disease gene LYSET is essential for lysosomal enzyme transport and viral infection
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DOI: 10.1126/science.abn5648
Abstract: Lysosomes are key degradative compartments of the cell. Transport to lysosomes relies on GlcNAc-1-phosphotransferase–mediated tagging of soluble enzymes with mannose 6-phosphate (M6P). GlcNAc-1-phosphotransferase deficiency leads to the severe lysosomal storage disorder mucolipidosis II (MLII). Several… read more here.
Keywords: viral infection; infection; glcnac phosphotransferase; phosphotransferase ... See more keywords