LYSET/TMEM251/GCAF is critical for autophagy and lysosomal function by regulating the mannose-6-phosphate (M6P) pathway
Sign Up to like & getrecommendations! Published in 2023 at "Autophagy"
DOI: 10.1080/15548627.2023.2167375
Abstract: ABSTRACT Vertebrate cells rely on mannose-6-phosphate (M6P) modifications to deliver most lumenal hydrolases to the lysosome. As a critical trafficking signal for lysosomal enzymes, the M6P biosynthetic pathway has been thoroughly investigated. However, its regulatory… read more here.
Keywords: phosphate m6p; pathway; lyset tmem251; mannose phosphate ... See more keywords
LYSET/TMEM251- a novel key component of the mannose-6-phosphate pathway.
Sign Up to like & getrecommendations! Published in 2023 at "Autophagy"
DOI: 10.1080/15548627.2023.2167376
Abstract: ​​Degradation of macromolecules delivered to lysosomes by processes such as autophagy or endocytosis is crucial for cellular function. Lysosomes require more than 60 soluble hydrolases in order to catabolize such macromolecules. These soluble hydrolases are… read more here.
Keywords: phosphate; lyset tmem251; mannose phosphate; glcnac phosphotransferase ... See more keywords