Intrinsic resistance of Enterococcus faecalis strains to ΦEf11 phage endolysin is associated with the presence of ΦEf11 prophage
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Virology"
DOI: 10.1007/s00705-020-04861-7
Abstract: The use of bacteriophage-encoded murein hydrolases (endolysins) is being actively explored as a means of controlling multidrug-resistant pathogens. Previously, we isolated and characterized one such enzyme, the phage ΦEf11 ORF28 lysin, which demonstrated profound antimicrobial… read more here.
Keywords: lysin; ef11; phage; enterococcus faecalis ... See more keywords
A Choline-Recognizing Monomeric Lysin, ClyJ-3m, Shows Elevated Activity against Streptococcus pneumoniae
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DOI: 10.1128/aac.00311-20
Abstract: Streptococcus pneumoniae is a leading pathogen for bacterial pneumonia, which can be treated with bacteriophage lysins harboring a conserved choline binding module (CBM). Such lysins regularly function as choline-recognizing dimers. Previously, we reported a pneumococcus-specific… read more here.
Keywords: choline recognizing; streptococcus; activity; clyj ... See more keywords
Lysin LysMK34 of Acinetobacter baumannii Bacteriophage PMK34 Has a Turgor Pressure-Dependent Intrinsic Antibacterial Activity and Reverts Colistin Resistance
Sign Up to like & getrecommendations! Published in 2020 at "Applied and Environmental Microbiology"
DOI: 10.1128/aem.01311-20
Abstract: A. baumannii is one of the most challenging pathogens for which development of new and effective antimicrobials is urgently needed. Colistin is a last-resort antibiotic, and even colistin-resistant A. baumannii strains exist. Here, we present… read more here.
Keywords: turgor pressure; baumannii; activity; colistin ... See more keywords
Exploiting Broad-Spectrum Chimeric Lysin to Cooperate with Mupirocin against Staphylococcus aureus-Induced Skin Infections and Delay the Development of Mupirocin Resistance
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.05050-22
Abstract: Staphylococcus aureus, as an Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species (ESKAPE) pathogen, can escape the elimination of existing antibiotics. At present, phages and phage lysins against S. aureus… read more here.
Keywords: staphylococcus aureus; resistance; mupirocin; aureus ... See more keywords
Antimicrobial activity of bovine NK-lysin-derived peptides on Mycoplasma bovis
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DOI: 10.1371/journal.pone.0197677
Abstract: Antimicrobial peptides (AMPs) are a diverse group of molecules which play an important role in the innate immune response. Bovine NK-lysins, a type of AMP, have been predominantly found in the granules of cytotoxic T-lymphocytes… read more here.
Keywords: lysin; microscopy; bovine; antimicrobial activity ... See more keywords
Genomic Variant in NK-Lysin Gene Is Associated with T Lymphocyte Subpopulations in Pigs
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DOI: 10.3390/genes13111985
Abstract: As an antimicrobial peptide, NK-lysin (NKL) plays an important role in the innate immune system of organisms. In this study, 300 piglets (68 Landrace pigs, 158 Large White pigs and 74 Songliao Black pigs) were… read more here.
Keywords: cd4 cd8; associated lymphocyte; lymphocyte subpopulations; gene ... See more keywords
Functional Characterization of Porcine NK-Lysin: A Novel Immunomodulator That Regulates Intestinal Inflammatory Response
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DOI: 10.3390/molecules26144242
Abstract: Porcine NK-Lysine (PNKL) is a new antimicrobial peptide (AMP) identified in the small intestine. In this study, PNKL protein was obtained through heterologous expression in Escherichia coli and was estimated by SDS-PAGE at 33 kDa.… read more here.
Keywords: lysin; coli k88; functional characterization; ipec cells ... See more keywords