Acetylome analysis of lysine acetylation in the plant pathogenic bacterium Brenneria nigrifluens
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DOI: 10.1002/mbo3.952
Abstract: Protein lysine acetylation, a dynamic and reversible posttranslational modification, plays a crucial role in several cellular processes, including cell cycle regulation, metabolism, enzymatic activities, and protein interactions. Brenneria nigrifluens is a pathogen of walnut trees… read more here.
Keywords: acetylation; analysis; brenneria nigrifluens; acetylation plant ... See more keywords
Lysine Acetylation Stoichiometry Analysis at the Proteome Level.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1936-0_7
Abstract: Lysine acetylation is a widespread posttranslational modification (PTM) in all kingdoms of live. A large number of proteins involved in most of biological pathways are targets of this PTM. The lysine acetylation is a reversible… read more here.
Keywords: acetylation stoichiometry; lysine acetylation; acetylation; stoichiometry analysis ... See more keywords
Dimethyl-Labeling-Based Quantification of the Lysine Acetylome and Proteome of Plants.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7225-8_5
Abstract: Photorespiratory enzymes in different cellular compartments have been reported to be posttranslational modified by phosphorylation, disulfide formation, S-nitrosylation, glutathionylation, and lysine acetylation. However, not much is known yet about the function of these modifications to… read more here.
Keywords: dimethyl labeling; lysine; quantification lysine; lysine acetylation ... See more keywords
Quantification of In Vitro Protein Lysine Acetylation by Reversed Phase HPLC.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9434-2_4
Abstract: Protein lysine acetylation is a reversible posttranslational modification that is catalyzed by a group of enzymes that are collectively referred to as lysine (K) acetyltransferases (KATs). These enzymes catalyze the transfer of the acetyl group… read more here.
Keywords: reversed phase; phase hplc; protein lysine; lysine acetylation ... See more keywords
Allyl isothiocyanate regulates lysine acetylation and methylation marks in an experimental model of malignant melanoma
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DOI: 10.1007/s00394-019-01925-6
Abstract: Objective(s) Isothiocyanates (ITCs) are biologically active plant secondary metabolites capable of mediating various biological effects including modulation of the epigenome. Our aim was to characterize the effect of allyl isothiocyanate (AITC) on lysine acetylation and… read more here.
Keywords: melanoma; methylation marks; malignant melanoma; lysine acetylation ... See more keywords
Non-enzymatic N-acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S-acetylated Thiol Intermediate Sensitive to Glyoxalase II
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.02.018
Abstract: Summary Acetyl coenzyme A (AcCoA), a key intermediate in mitochondrial metabolism, N-acetylates lysine residues, disrupting and, in some cases, regulating protein function. The mitochondrial lysine deacetylase Sirtuin 3 (Sirt3) reverses this modification with benefits reported… read more here.
Keywords: glyoxalase; acetylation; lysine; lysine acetylation ... See more keywords
Protein lysine acetylation: grease or sand in the gears of β-cell mitochondria?
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2019.09.011
Abstract: Mitochondria carry out many essential functions in metabolism. A central task is the oxidation of nutrients and the generation of ATP by oxidative phosphorylation. Mitochondrial metabolism needs to be tightly regulated for the cell to… read more here.
Keywords: sand gears; grease sand; lysine acetylation; protein lysine ... See more keywords
Lead-mediated inhibition of lysine acetylation and succinylation causes reproductive injury of the mouse testis during development.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology letters"
DOI: 10.1016/j.toxlet.2019.10.012
Abstract: Lead (Pb), a widespread heavy metal, may induce serious diseases, particularly male reproductive injury. However, the mechanisms by which Pb induces testicular injury remain unclear. In this paper, we established a mouse model of Pb-induced… read more here.
Keywords: reproductive injury; acetylation succinylation; injury; lysine acetylation ... See more keywords
Cellular substrate limitations of lysine acetylation turnover by sirtuins investigated with engineered futile cycle enzymes.
Sign Up to like & getrecommendations! Published in 2018 at "Metabolic engineering"
DOI: 10.1016/j.ymben.2018.04.022
Abstract: Metabolic activity and epigenetic regulation of gene expression are intimately coupled. The mechanisms linking the two are incompletely understood. Sirtuins catalyse the removal of acetyl groups from lysine side chains of proteins using NAD+ as… read more here.
Keywords: sirtase; turnover sirtuins; acetylation; acetylation turnover ... See more keywords
Proteomics and Lysine Acetylation Modification Reveal the Responses of Pakchoi (Brassica rapa L. ssp. chinensis) to Oxybenzone Stress.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c07852
Abstract: The broad-spectrum UV filter oxybenzone is toxic to plants at environmentally relevant concentrations. Lysine acetylation (LysAc) is one of the essential post-translational modifications (PTMs) in plant signaling responses. The goal of this study was to… read more here.
Keywords: oxybenzone treatment; oxybenzone; ssp chinensis; brassica rapa ... See more keywords
Hat1-Dependent Lysine Acetylation Targets Diverse Cellular Functions.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.9b00843
Abstract: Lysine acetylation has emerged as one of the most important post-translational modifications, regulating different biological processes. However, its regulation by lysine acetyltransferases is still unclear in most cases. Hat1 is a lysine acetyltransferase originally identified… read more here.
Keywords: acetylation; hat1 hat1; hat1; hat1 dependent ... See more keywords