Lysine to arginine mutagenesis of chlorotoxin enhances its cellular uptake
Sign Up to like & getrecommendations! Published in 2017 at "Peptide Science"
DOI: 10.1002/bip.23025
Abstract: Chlorotoxin (CTX), a disulfide‐rich peptide from the scorpion Leiurus quinquestriatus, has several promising biopharmaceutical properties, including preferential affinity for certain cancer cells, high serum stability, and cell penetration. These properties underpin its potential for use… read more here.
Keywords: ctx; arginine mutagenesis; lysine arginine; mutagenesis chlorotoxin ... See more keywords
Chemoproteomics Reveals Unexpected Lysine/Arginine-Specific Cleavage of Peptide Chains as a Potential Protein Degradation Machinery.
Sign Up to like & getrecommendations! Published in 2018 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.7b03237
Abstract: Proteins can undergo oxidative cleavage by in vitro metal-catalyzed oxidation (MCO) in either the α-amidation or the diamide pathway. However, whether oxidative cleavage of polypeptide-chain occurs in biological systems remains unexplored. We describe a chemoproteomic… read more here.
Keywords: protein; reveals unexpected; cleavage; chemoproteomics reveals ... See more keywords
Immunoglobulin-G Glycation by Fructose Leads to Structural Perturbations and Drop Off in Free Lysine and Arginine Residues.
Sign Up to like & getrecommendations! Published in 2017 at "Protein and peptide letters"
DOI: 10.2174/0929866524666170117142723
Abstract: Non-enzymatic glycation is the addition of free carbonyl group of reducing sugar to the free amino groups of proteins and leads to the formation of early glycation products and further into advanced glycation end products… read more here.
Keywords: lysine arginine; free lysine; arginine residues; glycation ... See more keywords
Photodynamic properties of lysine and arginine derivatives of bacteriopurpurinimide.
Sign Up to like & getrecommendations! Published in 2022 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2022-0192
Abstract: Background: O-propyloxime-N-propoxybacteriopurpurinimide methyl ester (3) is a near-infrared photosensitizer with confirmed in vivo anticancer activity. Methods: Conjugates of 3 with arginine (1) or lysine attached at an ε-amino group (2a) or α-amino group (2b) were… read more here.
Keywords: arginine derivatives; derivatives bacteriopurpurinimide; chemistry; lysine arginine ... See more keywords