ACSS2‐Mediated Histone H4 Lysine 12 Crotonylation (H4K12cr) Alleviates Colitis via Enhancing Transcription of CLDN7
Sign Up to like & getrecommendations! Published in 2025 at "Advanced Science"
DOI: 10.1002/advs.202500461
Abstract: Histone lysine crotonylation (Kcr), a highly conserved posttranslational modification, plays critical roles in various biological processes. Nevertheless, the dynamic alterations and functions of histone Kcr in inflammatory bowel disease (IBD) remain poorly explored. Herein, a… read more here.
Keywords: mediated histone; lysine crotonylation; acss2 mediated; histone lysine ... See more keywords
Cracking Lysine Crotonylation (Kcr): Enlightening a Promising Post‐Translational Modification
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DOI: 10.1002/cbic.202400639
Abstract: Lysine crotonylation (Kcr) is a recently discovered post‐translational modification (PTM). Both histone and non‐histone Kcr‐proteins have been associated with numerous diseases including cancer, acute kidney injury, HIV latency, and cardiovascular disease. Histone Kcr enhances gene… read more here.
Keywords: crotonylation; kcr; translational modification; crotonylation kcr ... See more keywords
Large-scale lysine crotonylation analysis reveals its potential role in spermiogenesis in the Chinese mitten crab Eriocheir sinensis.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2020.103891
Abstract: Lysine crotonylation (Kcr) is a recently-discovered type of post-translational modification. Although Kcr has been reported in many species, little is known about this process in crustaceans. In this study, pan anti-lysine crotonylation antibody enrichment and… read more here.
Keywords: sinensis; kcr; spermiogenesis; lysine crotonylation ... See more keywords
iKcr-PseEns: Identify lysine crotonylation sites in histone proteins with pseudo components and ensemble classifier.
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DOI: 10.1016/j.ygeno.2017.10.008
Abstract: Lysine crotonylation (Kcr) is an evolution-conserved histone posttranslational modification (PTM), occurring in both human somatic and mouse male germ cell genomes. It is important for male germ cell differentiation. Information of Kcr sites in proteins… read more here.
Keywords: identify lysine; lysine crotonylation; pseens identify; ikcr ... See more keywords
The mechanisms, regulations, and functions of histone lysine crotonylation
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DOI: 10.1038/s41420-024-01830-w
Abstract: Histone lysine crotonylation (Kcr) is a new acylation modification first discovered in 2011, which has important biological significance for gene expression, cell development, and disease treatment. In the past over ten years, numerous signs of… read more here.
Keywords: crotonylation; kcr modification; lysine crotonylation; histone lysine ... See more keywords
A deep learning model for prediction of lysine crotonylation sites by fusing multi-features based on multi-head self-attention mechanism
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DOI: 10.1038/s41598-025-04058-5
Abstract: Lysine crotonylation (Kcr) is an important post-translational modification, which is present in both histone and non-histone proteins, and plays a key role in a variety of biological processes such as metabolism and cell differentiation. Therefore,… read more here.
Keywords: deep learning; lysine crotonylation; fusing multi; language ... See more keywords
Chemical proteomic profiling of lysine crotonylation using minimalist bioorthogonal probes in mammalian cells
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DOI: 10.1039/d4sc06745b
Abstract: Protein lysine crotonylation has been found to be closely related to the occurrence and development of various diseases. Currently, site identification of crotonylation is mainly dependent on antibody enrichment; however, due to the cost, heterogeneity,… read more here.
Keywords: crotonylation; chemical; chemical proteomic; lysine crotonylation ... See more keywords
Comprehensive analysis of lysine crotonylation in proteome of maintenance hemodialysis patients
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DOI: 10.1097/md.0000000000012035
Abstract: Introduction: Histone post-translational modifications (PTMs) carry epigenetic information to regulate diverse cellular processes at the chromatin level. Crotonylation, one of the most important and common PTMs, plays a key role in the regulation of various… read more here.
Keywords: lysine crotonylation; analysis; lysine; crotonylation ... See more keywords
Lysine crotonylation of DgTIL1 at K72 modulates cold tolerance by enhancing DgnsLTP stability in chrysanthemum
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DOI: 10.1111/pbi.13533
Abstract: Summary Lysine crotonylation of proteins is a recently identified post‐translational modification (PTM) in plants. However, the function of lysine‐crotonylated proteins in response to abiotic stress in plants has not been reported. In this study, we… read more here.
Keywords: lysine crotonylation; dgtil1; crotonylation dgtil1; chrysanthemum ... See more keywords
Modulating Lysine Crotonylation in Cardiomyocytes Improves Myocardial Outcomes
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DOI: 10.1161/circresaha.122.321054
Abstract: Background: Ischemic heart disease is a major global public health challenge, and its functional outcomes remain poor. Lysine crotonylation (Kcr) was recently identified as a post-translational histone modification that robustly indicates active promoters. However, the… read more here.
Keywords: kcr; kcr sites; lysine crotonylation; injury ... See more keywords
Proteome-wide and lysine crotonylation profiling reveals the importance of crotonylation in chrysanthemum (Dendranthema grandiforum) under low-temperature
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DOI: 10.1186/s12864-020-07365-5
Abstract: Background Low-temperature severely affects the growth and development of chrysanthemum which is one kind of ornamental plant well-known and widely used in the world. Lysine crotonylation is a recently identified post-translational modification (PTM) with multiple… read more here.
Keywords: lysine crotonylation; low temperature; crotonylation; proteome wide ... See more keywords