Design, Synthesis, and Biological Evaluation of Lysine Demethylase 5 C Degraders
Sign Up to like & getrecommendations! Published in 2021 at "ChemMedChem"
DOI: 10.1002/cmdc.202000933
Abstract: Lysine demethylase 5 C (KDM5C) controls epigenetic gene expression and is attracting great interest in the field of chemical epigenetics. KDM5C has emerged as a therapeutic target for anti‐prostate cancer agents, and recently we identified triazole… read more here.
Keywords: design synthesis; biological evaluation; kdm5c; synthesis biological ... See more keywords
Discovery of a potent and selective inhibitor of histone lysine demethylase KDM4D.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113662
Abstract: Histone lysine demethylase 4D (KDM4D) plays an important role in the regulation of tumorigenesis, progression and drug resistance and has been considered a potential target for cancer treatment. However, there is still a lack of… read more here.
Keywords: potent selective; histone lysine; demethylase kdm4d; kdm4d ... See more keywords
3168 – INVESTIGATING THE ROLE OF THE KDM4A LYSINE DEMETHYLASE IN PEDIATRIC ACUTE MYELOID LEUKEMIA
Sign Up to like & getrecommendations! Published in 2019 at "Experimental Hematology"
DOI: 10.1016/j.exphem.2019.09.010
Abstract: In Canada, almost one third of childhood cancers are leukemias. Encouragingly, many of these pediatric leukemias are now treatable with a variety of anti-cancer drugs. Nonetheless, leukemia still accounts for an alarming ∼25% of cancer-related… read more here.
Keywords: myeloid leukemia; leukemia; lysine demethylase; acute myeloid ... See more keywords
Histone 3 lysine-27 demethylase KDM6A coordinates with KMT2B to play an oncogenic role in NSCLC by regulating H3K4me3
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-01449-y
Abstract: Aberrations in epigenetic modulation dysregulate transcription, playing a critical role in the developmental process of tumors, including lung cancer. Aberrant levels of the histone 3 lysine-27 demethylase KDM6A have been found in cancer and are… read more here.
Keywords: histone lysine; demethylase kdm6a; role; cancer ... See more keywords
Lysine demethylase 7a regulates murine anterior-posterior development by modulating the transcription of Hox gene cluster
Sign Up to like & getrecommendations! Published in 2020 at "Communications Biology"
DOI: 10.1038/s42003-020-01456-5
Abstract: Temporal and spatial colinear expression of the Hox genes determines the specification of positional identities during vertebrate development. Post-translational modifications of histones contribute to transcriptional regulation. Lysine demethylase 7A (Kdm7a) demethylates lysine 9 or 27… read more here.
Keywords: transcription; posterior hox; hox; lysine demethylase ... See more keywords
Lysine demethylase KDM5B down‐regulates SIRT3‐mediated mitochondrial glucose and lipid metabolism in diabetic neuropathy
Sign Up to like & getrecommendations! Published in 2022 at "Diabetic Medicine"
DOI: 10.1111/dme.14964
Abstract: Diabetic peripheral neuropathy (DPN) is a common neurological complication of diabetes mellitus without efficient interventions. Both lysine demethylase 5B (KDM5B) and sirtuin‐3 (SIRT3) have been found to regulate islet function and glucose homeostasis. KDM5B was… read more here.
Keywords: kdm5b; kdm5b regulates; demethylase kdm5b; regulates sirt3 ... See more keywords
Histone demethylase lysine demethylase 5B in development and cancer
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.13858
Abstract: Histone methylation is one of the most important chromatin posttranslational modifications. It has a range of influences on nuclear functions including epigenetic inheritance, transcriptional regulation and the maintenance of genome integrity. Changes in histone methylation… read more here.
Keywords: lysine demethylase; histone; demethylase; development cancer ... See more keywords
GSK-J4, a Specific Histone Lysine Demethylase 6A Inhibitor, Ameliorates Lipotoxicity to Cardiomyocytes via Preserving H3K27 Methylation and Reducing Ferroptosis
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cardiovascular Medicine"
DOI: 10.3389/fcvm.2022.907747
Abstract: Changes in modern lifestyle provoke a series of metabolic stresses such as hyperlipidemia. Excessive free fatty acids induce cardiomyocyte metabolic reprogramming and rearrangement of the lipid content of cardiomyocyte and promote oxidative stress. As a… read more here.
Keywords: histone lysine; inhibitor; lysine demethylase; gsk ... See more keywords
JMJD8 Functions as a Novel AKT1 Lysine Demethylase
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24010460
Abstract: JMJD8 is a protein from the JMJD family that only has the JmjC domain. Studies on the function of JMJD8 indicate that JMJD8 is involved in signaling pathways, including AKT/NF-κB, and thus affects cell proliferation… read more here.
Keywords: demethylase; jmjd8; novel akt1; lysine demethylase ... See more keywords
Lysine demethylase 3a in craniofacial and neural development during Xenopus embryogenesis.
Sign Up to like & getrecommendations! Published in 2019 at "International journal of molecular medicine"
DOI: 10.3892/ijmm.2018.4024
Abstract: Epigenetic modifier lysine demethylase 3a (Kdm3a) specifically demethylates mono‑ and di‑methylated ninth lysine of histone 3 and belongs to the Jumonji domain‑containing group of demethylases. Kdm3a serves roles during various biological and pathophysiological processes, including spermatogenesis and… read more here.
Keywords: xenopus; embryogenesis; neural development; development xenopus ... See more keywords
Lysine demethylase 1A exacerbates LPS-induced inflammation of vascular smooth muscle cells through modulation of NF-κB activation
Sign Up to like & getrecommendations! Published in 2020 at "Tropical Journal of Pharmaceutical Research"
DOI: 10.4314/tjpr.v19i3.4
Abstract: Purpose: To study the effect of lysine demethylase 1A (LSD1) on inflammatory responses of vascular smooth muscle cells (VSMCs), and investigate the mechanism. Methods: VSMCs were treated with lipopolysaccharide (LPS). Overexpression and knockdown of LSD1… read more here.
Keywords: lps induced; vascular smooth; muscle cells; smooth muscle ... See more keywords