Chemical Probes Reveal Sirt2's New Function as a Robust "Eraser" of Lysine Lipoylation.
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DOI: 10.1021/jacs.9b06913
Abstract: Lysine lipoylation, a highly conserved lysine PTM, plays a critical role in regulating cell metabolism. The catalytic activity of a number of vital metabolic proteins, such as pyruvate dehydrogenase (PDH), depends on lysine lipoylation. Despite… read more here.
Keywords: lipoylation; sirt2; lysine lipoylation; chemical probes ... See more keywords