Lysine methylation signaling of non-histone proteins in the nucleus
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-019-03142-0
Abstract: Lysine methylation, catalyzed by protein lysine methyltransferases (PKMTs), is a central post-translational modification regulating many signaling pathways. It has direct and indirect effects on chromatin structure and transcription. Accumulating evidence suggests that dysregulation of PKMT… read more here.
Keywords: methylation; lysine methylation; histone proteins; non histone ... See more keywords
Nanofluidic Device for Detection of Lysine Methylpeptides and Sensing of Lysine Methylation.
Sign Up to like & getrecommendations! Published in 2023 at "Analytical chemistry"
DOI: 10.1021/acs.analchem.3c01074
Abstract: Protein methylation is the smallest possible yet vitally important post-translational modification (PTM). This small and chemically inert addition in proteins makes the analysis of methylation more challenging, thus calling for an efficient tool for the… read more here.
Keywords: methylation; lysine methylpeptides; chemistry; detection ... See more keywords
Effect of Histone Lysine Methylation on DNA Lesion Reactivity in Nucleosome Core Particles.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00049
Abstract: Lysine methylation is a common post-translational histone modification that regulates transcription and gene expression. The lysine residues in the histone tail also react with damaged nucleotides in chromatin, including abasic sites and N7-methyl-2'-deoxyguanosine, the major… read more here.
Keywords: methylation; lysine methylation; core particles; dna ... See more keywords
Quantitative Analysis of Nonhistone Lysine Methylation Sites and Lysine Demethylases in Breast Cancer Cell Lines.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of proteome research"
DOI: 10.1021/acs.jproteome.4c00685
Abstract: Growing evidence shows that lysine methylation is a widespread protein post-translational modification (PTM) that regulates protein function on histone and nonhistone proteins. Numerous studies have demonstrated that the dysregulation of lysine methylation mediators contributes to… read more here.
Keywords: cancer; methylation; nonhistone; cell lines ... See more keywords
SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Cell Research"
DOI: 10.1038/s41422-024-01013-3
Abstract: While lysine methylation is well-known for regulating gene expression transcriptionally, its implications in translation have been largely uncharted. Trimethylation at lysine 22 (K22me3) on RPL40, a core ribosomal protein located in the GTPase activation center… read more here.
Keywords: lysine methylation; translation; catalyzes rpl40; rpl40 k22me3 ... See more keywords
Histone tales: lysine methylation, a protagonist in Arabidopsis development.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of experimental botany"
DOI: 10.1093/jxb/erz435
Abstract: Histone methylation plays a fundamental role in the epigenetic regulation of gene expression driven by developmental and environmental cues in plants, including Arabidopsis. Histone methyltransferases and demethylases act as "writers" and "erasers" of methylation at… read more here.
Keywords: methylation; lysine methylation; histone; arabidopsis development ... See more keywords
A new target of multiple lysine methylation in bacteria
Sign Up to like & getrecommendations! Published in 2024 at "Journal of Bacteriology"
DOI: 10.1128/jb.00325-24
Abstract: ABSTRACT The methylation of ε-amino groups in protein lysine residues is an important posttranslational modification in eukaryotes. This modification plays a pivotal role in the regulation of diverse biological processes, including epigenetics, transcriptional control, and… read more here.
Keywords: methylation; multiple lysine; lysine residues; physiology ... See more keywords
iMethylK_pseAAC: Improving Accuracy of Lysine Methylation Sites Identification by Incorporating Statistical Moments and Position Relative Features into General PseAAC via Chou’s 5-steps Rule
Sign Up to like & getrecommendations! Published in 2019 at "Current Genomics"
DOI: 10.2174/1389202920666190809095206
Abstract: Background: Methylation is one of the most important post-translational modifications in the human body which usually arises on lysine among the most intensely modified residues. It performs a dynamic role in numerous biological procedures, such… read more here.
Keywords: methylation sites; methylation; lysine methylation; pseaac ... See more keywords
Histone Lysine Methylation Modification and Its Role in Vascular Calcification
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2022.863708
Abstract: Histone methylation is an epigenetic change mediated by histone methyltransferase, and has been connected to the beginning and progression of several diseases. The most common ailments that affect the elderly are cardiovascular and cerebrovascular disorders.… read more here.
Keywords: methylation modification; methylation; histone; role ... See more keywords
Writing and Reading Histone H3 Lysine 9 Methylation in Arabidopsis
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2020.00452
Abstract: In eukaryotes, histone H3 lysine 9 methylation (H3K9me) mediates the silencing of invasive and repetitive sequences by preventing the expression of aberrant gene products and the activation of transposition. In Arabidopsis, while it is well… read more here.
Keywords: methylation; lysine methylation; histone lysine; arabidopsis ... See more keywords
Mass Spectrometry for Lysine Methylation: Principles, Progress, and Prospects
Sign Up to like & getrecommendations! Published in 2025 at "Biomedicines"
DOI: 10.3390/biomedicines13112825
Abstract: Lysine methylation is a regulatory post-translational modification with diverse roles across both histone and non-histone proteins. Despite its biological relevance, comprehensive characterization of lysine methylation remains analytically challenging due to its low stoichiometry, subtle mass… read more here.
Keywords: spectrometry lysine; methylation; mass spectrometry; lysine methylation ... See more keywords