Histone lysine methyltransferase SETDB2 suppresses NRF2 to restrict tumor progression and modulates chemotherapy sensitivity in lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Medicine"
DOI: 10.1002/cam4.5451
Abstract: Aberrant epigenetic remodeling represents a molecular hallmark in lung adenocarcinoma (LUAD). We aim to investigate the biological roles of SETDB2 and its underlying associations with oxidative stress, providing therapeutic targets for individualized treatment of LUAD. read more here.
Keywords: methyltransferase setdb2; lung adenocarcinoma; histone lysine; lung ... See more keywords
Dissecting the Kinetic Mechanism of Human Lysine Methyltransferase 2D and Its Interactions with the WRAD2 Complex
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00385
Abstract: Human lysine methyltransferase 2D (hKMT2D) is an epigenetic writer catalyzing the methylation of histone 3 lysine 4. hKMT2D by itself has little catalytic activity and reaches full activation as part of the WRAD2 complex, additionally… read more here.
Keywords: set domain; wrad2 complex; human lysine; mechanism ... See more keywords
Protein Lysine Methyltransferase SMYD2: A Promising Small Molecule Target for Cancer Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c00325
Abstract: In epigenetic research, the abnormality of protein methylation modification is closely related to the occurrence and development of tumors, which stimulates the interest of researchers in protein methyltransferase research and the efforts to develop corresponding… read more here.
Keywords: small molecule; molecule; protein lysine; methyltransferase smyd2 ... See more keywords
Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c02059
Abstract: Identification of structurally novel inhibitors of lysine methyltransferase G9a has been a subject of intense research in cancer epigenetics. Starting with the high-throughput screening (HTS) hit rac-10a obtained from the chemical library of the University… read more here.
Keywords: substrate competitive; methyltransferase g9a; discovery novel; g9a ... See more keywords
Selective, small molecule co-factor binding site inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax (SET) domain containing lysine methyltransferase.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.9b00112
Abstract: The first co-factor binding site chemical probe for a SET domain containing protein lysine methyltransferase (PKMT) is reported. Protein methyltransferases require S-adenosylmethionine (SAM) as a co-factor (methyl donor) for enzymatic activity. However, SAM itself represents… read more here.
Keywords: domain containing; chemistry; lysine methyltransferase; site ... See more keywords
The role of SET domain containing lysine methyltransferase 7 in tumorigenesis and development
Sign Up to like & getrecommendations! Published in 2022 at "Cell Cycle"
DOI: 10.1080/15384101.2022.2122257
Abstract: ABSTRACT SET domain containing lysine methyltransferase 7 (SETD7) belongs to the protein lysine methyltransferase family and can catalyze the monomethylation of histone H3K4, which plays a vital role in the regulation of cell cycle, cell… read more here.
Keywords: set domain; role; tumor; development ... See more keywords
Augmented Production of Platelets From Cord Blood With Euchromatic Histone Lysine Methyltransferase Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "Stem Cells Translational Medicine"
DOI: 10.1093/stcltm/szac048
Abstract: Abstract Cord blood hematopoietic stem/progenitor cells (CB-HSPCs) have emerged as a promising supply for functional platelets to potentially alleviate the increasing demand for platelet transfusions, but the clinical application has been limited by the undefined… read more here.
Keywords: histone lysine; euchromatic histone; cord blood; production ... See more keywords
Histone lysine methyltransferase G9a is a novel epigenetic target for the treatment of hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15528
Abstract: Histone H3 lysine 9 dimethylation (H3K9me2) is mainly regulated by the histone lysine methyltransferase G9a and is associated with the repression of transcription. However, both the role of G9a and the significance of H3K9me2 in… read more here.
Keywords: hcc; histone lysine; lysine methyltransferase; growth ... See more keywords
Structure, activity and function of the lysine methyltransferase SETD5
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1089527
Abstract: SET domain-containing 5 (SETD5) is an uncharacterized member of the protein lysine methyltransferase family and is best known for its transcription machinery by methylating histone H3 on lysine 36 (H3K36). These well-characterized functions of SETD5… read more here.
Keywords: structure activity; activity function; methyltransferase; lysine methyltransferase ... See more keywords
Lysine Methyltransferase NSD1 and Cancers: Any Role in Melanoma?
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14194865
Abstract: Simple Summary Epigenetic events, which comprise post-translational modifications of histone tails or DNA methylation, control gene expression by altering chromatin structure without change in the DNA sequence. Histone tails modifications are driven by specific cellular… read more here.
Keywords: methylation; histone; melanoma; role ... See more keywords
Photooxidation of A2E by Blue Light Regulates Heme Oxygenase 1 Expression via NF-κB and Lysine Methyltransferase 2A in ARPE-19 Cells
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12111698
Abstract: Background: N-retinylidene-N-retinylethanolamine (A2E) is a component of drusen that accumulates in retinal cells and induces oxidative stress through photooxidation, such as blue light (BL). We found that the heme oxygenase 1 (HMOX1) gene responds sensitively… read more here.
Keywords: heme oxygenase; expression; blue light; arpe cells ... See more keywords