DMSO‐Related Effects on Ligand‐Binding Properties of Lysine Methyltransferases G9a and SETD8
Sign Up to like & getrecommendations! Published in 2024 at "ChemBioChem"
DOI: 10.1002/cbic.202300809
Abstract: Being the standard solvent for preparing stock solutions of compounds for drug discovery, DMSO is always present in assay buffers in concentrations ranging from 0.1 % to 5 % (v/v). Even at the lowest concentrations, DMSO‐containing solutions… read more here.
Keywords: methyltransferases g9a; effects ligand; lysine methyltransferases; related effects ... See more keywords
A direct label-free MALDI-TOF mass spectrometry based assay for the characterization of inhibitors of protein lysine methyltransferases
Sign Up to like & getrecommendations! Published in 2017 at "Analytical and Bioanalytical Chemistry"
DOI: 10.1007/s00216-017-0319-5
Abstract: Histone lysine methylation is associated with essential biological functions like transcription activation or repression, depending on the position and the degree of methylation. This post-translational modification is introduced by protein lysine methyltransferases (KMTs) which catalyze… read more here.
Keywords: methylation; maldi tof; tof mass; lysine methyltransferases ... See more keywords
Clinicopathologic significance of protein lysine methyltransferases in cancer
Sign Up to like & getrecommendations! Published in 2020 at "Clinical Epigenetics"
DOI: 10.1186/s13148-020-00897-3
Abstract: Protein lysine methyltransferases (PKMTs) constitute a large family of approximately 50 chromatin modifiers that mono-, di- and/or tri-methylate lysine residues on histone and non-histone substrates. With the advent of The Cancer Genome Atlas, it became… read more here.
Keywords: protein; clinicopathologic significance; lysine methyltransferases; cancer ... See more keywords
Protein Lysine Methyltransferases Inhibitors.
Sign Up to like & getrecommendations! Published in 2022 at "Current medicinal chemistry"
DOI: 10.2174/0929867329666220829151257
Abstract: Protein lysine methylation is a significant protein post-translational modification (PTMs), and has a key function in epigenetic regulation. Protein lysine methyltransferase (PKMTs) mainly catalyze the lysine methylation of various core histones, but also catalyze a… read more here.
Keywords: chemistry; methyltransferases inhibitors; pkmts; protein lysine ... See more keywords
Targeting Epigenetic Changes Mediated by Members of the SMYD Family of Lysine Methyltransferases
Sign Up to like & getrecommendations! Published in 2023 at "Molecules"
DOI: 10.3390/molecules28042000
Abstract: A comprehensive understanding of the mechanisms involved in epigenetic changes in gene expression is essential to the clinical management of diseases linked to the SMYD family of lysine methyltransferases. The five known SMYD enzymes catalyze… read more here.
Keywords: family lysine; smyd family; family; lysine methyltransferases ... See more keywords