Context‐Dependence of the Reactivity of Cysteine and Lysine Residues
Sign Up to like & getrecommendations! Published in 2022 at "Chembiochem"
DOI: 10.1002/cbic.202200258
Abstract: The S‐alkylation of Cys residues with a maleimide and the Nϵ‐acylation of Lys residues with an N‐hydroxysuccinimide (NHS) ester are common methods for bioconjugation. Using Cys and Lys derivatives as proxies, we assessed differences in… read more here.
Keywords: reactivity cysteine; cysteine lysine; dependence reactivity; reactivity ... See more keywords
Non-enzymatic N-acetylation of Lysine Residues by AcetylCoA Often Occurs via a Proximal S-acetylated Thiol Intermediate Sensitive to Glyoxalase II
Sign Up to like & getrecommendations! Published in 2017 at "Cell Reports"
DOI: 10.1016/j.celrep.2017.02.018
Abstract: Summary Acetyl coenzyme A (AcCoA), a key intermediate in mitochondrial metabolism, N-acetylates lysine residues, disrupting and, in some cases, regulating protein function. The mitochondrial lysine deacetylase Sirtuin 3 (Sirt3) reverses this modification with benefits reported… read more here.
Keywords: glyoxalase; acetylation; lysine; lysine acetylation ... See more keywords
Glycation of glucose sensitive lysine residues K36, K438 and K549 of albumin is associated with prediabetes.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of proteomics"
DOI: 10.1016/j.jprot.2019.103481
Abstract: Prediabetes is a risk factor for the development of diabetes. Early diagnosis of prediabetes may prevent the onset and progression of diabetes and its associated complications. Therefore, this study aimed at identification of novel markers… read more here.
Keywords: k36 k438; glycated peptides; residues k36; glucose sensitive ... See more keywords
Chiral Posttranslational Modification to Lysine ε-Amino Groups.
Sign Up to like & getrecommendations! Published in 2022 at "Accounts of chemical research"
DOI: 10.1021/acs.accounts.2c00115
Abstract: ConspectusThe sophistication of proteomic analysis has revealed that protein lysine residues are posttranslationally modified by a variety of acyl groups. Protein lysine acetylation regulates metabolism, gene expression, and microtubule formation and has been extensively studied;… read more here.
Keywords: chiral posttranslational; modification lysine; posttranslational modification; lysine ... See more keywords
Comparison of the Deacylase and Deacetylase Activity of Zinc-Dependent HDACs.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00321
Abstract: The acetylation status of lysine residues on histone proteins has long been attributed to a balance struck between the catalytic activity of histone acetyl transferases and histone deacetylases (HDAC). HDACs were identified as the sole… read more here.
Keywords: zinc dependent; dependent hdacs; hdacs; biology ... See more keywords
PhoglyStruct: Prediction of phosphoglycerylated lysine residues using structural properties of amino acids
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-36203-8
Abstract: The biological process known as post-translational modification (PTM) contributes to diversifying the proteome hence affecting many aspects of normal cell biology and pathogenesis. There have been many recently reported PTMs, but lysine phosphoglycerylation has emerged… read more here.
Keywords: phosphoglycerylated lysine; amino acids; phoglystruct prediction; non phosphoglycerylated ... See more keywords
Nucleotide-binding sites can enhance N-acylation of nearby protein lysine residues
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DOI: 10.1038/s41598-020-77261-1
Abstract: Acyl-CoAs are reactive metabolites that can non-enzymatically S-acylate and N-acylate protein cysteine and lysine residues, respectively. N-acylation is irreversible and enhanced if a nearby cysteine residue undergoes an initial reversible S-acylation, as proximity leads to… read more here.
Keywords: nucleotide binding; acylation; binding sites; lysine residues ... See more keywords
Genetic Modification of the AAV5 Capsid with Lysine Residues Results in a Lung-tropic, Liver-detargeted Gene Transfer Vector.
Sign Up to like & getrecommendations! Published in 2022 at "Human gene therapy"
DOI: 10.1089/hum.2021.200
Abstract: Intravenous (IV) administration of naturally occurring adeno-associated virus (AAV) vectors are liver tropic, with a significant proportion of the total vector dose mediating gene expression in liver hepatocytes. AAV capsids that are directed towards other… read more here.
Keywords: lung; vector; capsid; aav5 ... See more keywords
Conserved lysine residues in decorin binding proteins of Borrelia garinii are critical in adhesion to human brain microvascular endothelial cells
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Microbiology"
DOI: 10.1111/mmi.14687
Abstract: Lyme borreliosis is a tick‐borne disease caused by Borrelia burgdorferi sensu lato spirochetes (Lyme borreliae). When the disease affects the central nervous system, it is referred to as neuroborreliosis. In Europe, neuroborreliosis is most often… read more here.
Keywords: binding proteins; borrelia garinii; decorin binding; lyme borreliae ... See more keywords
Role of lysine residues of the Magnaporthe oryzae effector AvrPiz‐t in effector‐ and PAMP‐triggered immunity
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DOI: 10.1111/mpp.12779
Abstract: Summary Magnaporthe oryzae is an important fungal pathogen of both rice and wheat. However, how M. oryzae effectors modulate plant immunity is not fully understood. Previous studies have shown that the M. oryzae effector AvrPiz‐t… read more here.
Keywords: avrpiz; magnaporthe oryzae; effector avrpiz; lysine residues ... See more keywords
Preparation of Affinity Purified Antibodies against ε-Glutaryl-Lysine Residues in Proteins for Investigation of Glutarylated Proteins in Animal Tissues
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11081168
Abstract: The glutarylation of lysine residues in proteins attracts attention as a possible mechanism of metabolic regulation, perturbed in pathologies. The visualization of protein glutarylation by antibodies specific to ε-glutaryl-lysine residues may be particularly useful to… read more here.
Keywords: glutarylated proteins; glutarylation; glutaryl lysine; lysine residues ... See more keywords