Lysine-selective molecular tweezers are cell penetrant and concentrate in lysosomes
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DOI: 10.1038/s42003-021-02603-2
Abstract: Lysine-selective molecular tweezers are promising drug candidates against proteinopathies, viral infection, and bacterial biofilm. Despite demonstration of their efficacy in multiple cellular and animal models, important questions regarding their mechanism of action, including cell penetrance… read more here.
Keywords: molecular tweezers; penetrant concentrate; tweezers cell; lysine selective ... See more keywords
A pyridinium-based strategy for lysine-selective protein modification and chemoproteomic profiling in live cells
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DOI: 10.1039/d3sc05766f
Abstract: Protein active states are dynamically regulated by various modifications; thus, endogenous protein modification is an important tool for understanding protein functions and networks in complicated biological systems. Here we developed a new pyridinium-based approach to… read more here.
Keywords: selective protein; pyridinium based; lysine selective; protein ... See more keywords