Combination of lysine‐specific demethylase 6A (KDM6A) and mismatch repair (MMR) status is a potential prognostic factor in colorectal cancer
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Medicine"
DOI: 10.1002/cam4.3602
Abstract: To evaluate the relationship between the DNA mismatch repair (MMR) status and histone lysine‐specific demethylase 6A (KDM6A) on the prognosis of colorectal cancer (CRC). read more here.
Keywords: lysine specific; repair mmr; mmr status; cancer ... See more keywords
Design, Synthesis, and Evaluation of (2-Aminocyclopropyl)phenyl Derivatives as Novel Positron Emission Tomography Imaging Agents for Lysine-Specific Demethylase 1 in the Brain.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.0c01937
Abstract: Dysregulation of histone H3 lysine 4 (H3K4) methylation is implicated in the pathogenesis of neurodevelopmental disorders. Lysine-specific demethylase 1 (LSD1) determines the methylation status of H3K4 through flavin adenine dinucleotide (FAD)-mediated histone demethylation. Therefore, LSD1… read more here.
Keywords: aminocyclopropyl phenyl; lysine specific; positron emission; specific demethylase ... See more keywords
Lysine-Specific Demethylase 1 Promises to Be a Novel Target in Cancer Drug Resistance: Therapeutic Implications.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01527
Abstract: Chemotherapy, targeted therapy, and immunotherapy are effective against most tumors, but drug resistance remains a barrier to successful treatment. Lysine-specific demethylase 1 (LSD1), a member of histone demethylation modifications, can regulate invasion, metastasis, apoptosis, and… read more here.
Keywords: cancer drug; resistance; specific demethylase; lysine specific ... See more keywords
Discovery of new potent lysine specific histone demythelase-1 inhibitors (LSD-1) using structure based and ligand based molecular modelling and machine learning
Sign Up to like & getrecommendations! Published in 2022 at "RSC Advances"
DOI: 10.1039/d2ra05102h
Abstract: Lysine-specific histone demethylase 1 (LSD-1) is an epigenetic enzyme that oxidatively cleaves methyl groups from monomethyl and dimethyl Lys4 of histone H3 and is highly overexpressed in different types of cancer. Therefore, it has been… read more here.
Keywords: specific histone; histone; machine learning; modelling machine ... See more keywords
MP38-08 SELECTIVE LYSINE SPECIFIC DEMETHYLASE 1 INHIBITOR, NCL1, COULD CAUSE TESTICULAR TOXICITY VIA THE REGULATION OF APOPTOSIS
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Urology"
DOI: 10.1097/ju.0000000000000887.08
Abstract: INTRODUCTION AND OBJECTIVE: Recent studies show that epigenetic alterations, such as lysine-specific demethylase 1 (LSD1), lead to oncogenic activation, suggesting such alterations as therapeutic target molecules. However, studies evaluating the effect of LSD1 inhibitors on… read more here.
Keywords: inhibitor ncl1; toxicity; lysine specific; apoptosis ... See more keywords
Targeting the lysine-specific demethylase 1 rewires kinase networks and primes leukemia cells for kinase inhibitor treatment
Sign Up to like & getrecommendations! Published in 2022 at "Science Signaling"
DOI: 10.1126/scisignal.abl7989
Abstract: Most tumor types either fail to respond or become resistant to kinase inhibitors, often because of compensatory prosurvival pathways in the cancer cell’s broader signaling circuitry. Here, we found that intrinsic resistance to kinase inhibitors… read more here.
Keywords: kinase; activity; kinase inhibitors; specific demethylase ... See more keywords
Lysine-specific demethylase 1A (LSD1) restricts ex vivo propagation of human HSCs and is a target of UM171.
Sign Up to like & getrecommendations! Published in 2020 at "Blood"
DOI: 10.1182/blood.2020005827
Abstract: Culture conditions in which hematopoietic stem cells (HSCs) can be expanded for clinical benefit are highly sought after. Here, we report that inhibition of the epigenetic regulator Lysine-specific histone demethylase 1A (LSD1) induces a rapid… read more here.
Keywords: hscs; demethylase lsd1; lysine specific;
Roles of lysine-specific demethylase 1 (LSD1) in homeostasis and diseases
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biomedical Science"
DOI: 10.1186/s12929-021-00737-3
Abstract: Lysine-specific demethylase 1 (LSD1) targets mono- or di-methylated histone H3K4 and H3K9 as well as non-histone substrates and functions in the regulation of gene expression as a transcriptional repressor or activator. This enzyme plays a… read more here.
Keywords: lysine specific; cancer; demethylase lsd1; specific demethylase ... See more keywords
Lysine-specific demethylase 6A upregulates cadherin-1 and accelerates gastric cancer growth.
Sign Up to like & getrecommendations! Published in 2023 at "Current pharmaceutical biotechnology"
DOI: 10.2174/1389201024666230320100504
Abstract: Background Gastric cancer (GC) ranks fifth among all common malignancies globally. Genetic research has revealed several genes that are frequently dis-regulated in GC, such as lysine-specific demethylase 6A (KDM6A) and cadherin-1 (CDH1). This study aimed… read more here.
Keywords: expression; gastric cancer; specific demethylase; kdm6a ... See more keywords
Role of Lysine Specific Demethylase 1 and Its Small Molecule Inhibitors in Glioblastoma Multiforme Therapy.
Sign Up to like & getrecommendations! Published in 2022 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520622666220421092414
Abstract: Glioblastoma multiforme (GBM) is among the most critical and aggressive carcinomas of CNS, characterised by poor prognosis, low survival rate and difficult clinical correlations. Current treatment opportunities have proved to be insufficient due to high… read more here.
Keywords: demethylase; small molecule; gbm; glioblastoma multiforme ... See more keywords
A Pan-Cancer Analysis Revealing the Dual Roles of Lysine (K)-Specific Demethylase 6B in Tumorigenesis and Immunity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2022.912003
Abstract: Introduction: Epigenetic-targeted therapy has been increasingly applied in the treatment of cancers. Lysine (K)-specific demethylase 6B (KDM6B) is an epigenetic enzyme involved in the coordinated control between cellular intrinsic regulators and the tissue microenvironment whereas… read more here.
Keywords: kdm6b; pan cancer; analysis; specific demethylase ... See more keywords