Lysine Stapling Screening Provides Stable and Low Toxic Cationic Antimicrobial Peptides Combating Multidrug-Resistant Bacteria In Vitro and In Vivo.
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DOI: 10.1021/acs.jmedchem.1c01754
Abstract: Cationic antimicrobial peptides (CAMPs) are promising for treatment of multidrug-resistant (MDR) bacteria-caused infections. However, clinical application of CAMPs has been hampered mostly due to their poor proteolytic stability and hemolytic toxicity. Recently, lysine-stapled CAMPs developed… read more here.
Keywords: cationic antimicrobial; antimicrobial peptides; stapling screening; lysine stapling ... See more keywords