H3K9me3, H3K36me3, and H4K20me3 Expression Correlates with Patient Outcome in Esophageal Squamous Cell Carcinoma as Epigenetic Markers
Sign Up to like & getrecommendations! Published in 2019 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-019-05529-2
Abstract: BackgroundHistone methylation, as an essential pattern of posttranslational modifications, contributes to multiple cancer-related biological processes. Dysregulation of histone methylation is now considered a biomarker for cancer prognosis.AimsThis study investigated and evaluated the potential role of… read more here.
Keywords: prognosis; lysine trimethylation; h4k20me3; expression ... See more keywords
Histone H3 lysine 4 trimethylation in sperm is transmitted to the embryo and associated with diet-induced phenotypes in the offspring.
Sign Up to like & getrecommendations! Published in 2021 at "Developmental cell"
DOI: 10.1016/j.devcel.2021.01.014
Abstract: A father's lifestyle impacts offspring health; yet, the underlying molecular mechanisms remain elusive. We hypothesized that a diet that changes methyl donor availability will alter the sperm and embryo epigenomes to impact embryonic gene expression… read more here.
Keywords: histone lysine; lysine trimethylation; gene expression; transmitted embryo ... See more keywords
Broad domains of histone 3 lysine 4 trimethylation are associated with transcriptional activation in CA1 neurons of the hippocampus during memory formation
Sign Up to like & getrecommendations! Published in 2019 at "Neurobiology of Learning and Memory"
DOI: 10.1016/j.nlm.2019.04.009
Abstract: Transcriptional changes in the hippocampus are required for memory formation, and these changes are regulated by numerous post-translational modifications of chromatin-associated proteins. One of the epigenetic marks that has been implicated in memory formation is… read more here.
Keywords: memory formation; histone lysine; lysine trimethylation; h3k4me3 ... See more keywords
Chronic Hypergravity Induces a Modification of Histone H3 Lysine 27 Trimethylation at TCRβ Locus in Murine Thymocytes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137133
Abstract: Gravity changes are major stressors encountered during spaceflight that affect the immune system. We previously evidenced that hypergravity exposure during gestation affects the TCRβ repertoire of newborn pups. To identify the mechanisms underlying this observation,… read more here.
Keywords: hypergravity; lysine trimethylation; tcr locus;
Bioinformatics analysis of the network of histone H3 lysine 9 trimethylation in acute myeloid leukaemia
Sign Up to like & getrecommendations! Published in 2020 at "Oncology Reports"
DOI: 10.3892/or.2020.7627
Abstract: Changes in histone H3 lysine 9 trimethylation (H3K9me3) may be related to the development of drug-resistant acute myeloid leukaemia (AML); insights into the network of H3K9me3 may improve patient prognosis. Patient data were derived from… read more here.
Keywords: histone lysine; network; lysine trimethylation; myeloid leukaemia ... See more keywords