Lysophosphatidic acid induces the crosstalk between the endovascular human trophoblast and endothelial cells in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.27358
Abstract: Spiral artery remodeling at the maternal–fetal interface is crucial for successful pregnancy and requires the interaction between the first trimester trophoblast and the endothelial cells of the maternal vessels. However, the precise mechanism of this… read more here.
Keywords: lysophosphatidic acid; endothelial cells; lpa; trophoblast endothelial ... See more keywords
Inhibition of lysophosphatidic acid receptor 6 upregulated by the choline‐deficient l‐amino acid‐defined diet prevents hepatocarcinogenesis in mice
Sign Up to like & getrecommendations! Published in 2023 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23516
Abstract: Hepatocellular carcinoma (HCC) is one of the most worrying tumors worldwide today, and its epidemiology is on the rise. Traditional pharmacological approaches have shown unfavorable results and exhibited many side effects. Hence, there is a… read more here.
Keywords: lysophosphatidic acid; hepatocarcinogenesis; acid; deficient amino ... See more keywords
Activity and clinical relevance of autotaxin and lysophosphatidic acid pathways in high-grade serous carcinoma
Sign Up to like & getrecommendations! Published in 2018 at "Virchows Archiv"
DOI: 10.1007/s00428-018-2418-x
Abstract: The aim of this study was to analyze the expression, biological role and clinical relevance of autotaxin (ATX), the enzyme synthetizing lysophosphatidic acid (LPA), and LPA receptors (LPAR) in high-grade serous carcinoma (HGSC). mRNA expression… read more here.
Keywords: grade serous; clinical relevance; high grade; expression ... See more keywords
Lysophosphatidic acid signaling regulates the KLF9-PPARγ axis in human induced pluripotent stem cell-derived neurons.
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2017.07.082
Abstract: Lysophosphatidic acid (LPA) is a lipid signaling molecule that plays several significant roles in the nervous system during development and injury. In this study, we differentiated human induced pluripotent stem cells (iPSCs) into neurons as… read more here.
Keywords: human induced; derived neurons; pluripotent stem; induced pluripotent ... See more keywords
2-O-Carba-oleoyl cyclic phosphatidic acid induces glial proliferation through the activation of lysophosphatidic acid receptor
Sign Up to like & getrecommendations! Published in 2018 at "Brain Research"
DOI: 10.1016/j.brainres.2017.12.031
Abstract: Lysophosphatidic acid (LPA) and cyclic phosphatidic acid (cPA) are one of the lipid mediators regulating cell proliferation and differentiation through the activation of LPA receptors. An LPA receptor-mediated signal is important for the development of… read more here.
Keywords: lysophosphatidic acid; proliferation; activation; receptor ... See more keywords
The SH3 domain of Caskin1 binds to lysophosphatidic acid suggesting a direct role for the lipid in intracellular signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2017.01.019
Abstract: Src homology 3 or SH3 domains constitute one of the most common protein domains in signal transduction, generally characterized by their binding to proline-rich sequences on interacting signaling proteins. Caskin1, a scaffold protein regulating cortical… read more here.
Keywords: caskin1; sh3 domain; lysophosphatidic acid; proline rich ... See more keywords
Effects of micro wet milling on bioaccessibility of phosphatidic acid and lysophosphatidic acid in komatsuna during in vitro digestion.
Sign Up to like & getrecommendations! Published in 2019 at "Food research international"
DOI: 10.1016/j.foodres.2019.01.021
Abstract: Foods rich in phosphatidic acid (PA) can ameliorate stomach ulcers in mice by hydrolysis of PA to lysophosphatidic acid (LPA). In this study, PA-rich komatsuna was produced using the micro wet milling (MWM) system, which… read more here.
Keywords: komatsuna; digestion; micro wet; lysophosphatidic acid ... See more keywords
Oxidative stress mediated myocardial lysophosphatidic acid signaling
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.206
Abstract: The bioactive lysophosphatidic acid (LPA) plays a well-known role in atherosclerotic disease, whereas, its role in myocardial function remains virtually unexplored. Following acute myocardial infarction, serum LPA concentration rises by six-fold over control human subjects,… read more here.
Keywords: autotaxin; lpa; lpp3; lysophosphatidic acid ... See more keywords
Lysophosphatidic acid provides a missing link between osteoarthritis and joint neuropathic pain.
Sign Up to like & getrecommendations! Published in 2017 at "Osteoarthritis and cartilage"
DOI: 10.1016/j.joca.2016.08.016
Abstract: OBJECTIVE Emerging evidence suggests that osteoarthritis (OA) has a neuropathic component; however, the identity of the molecules responsible for this peripheral neuropathy is unknown. The aim of this study was to determine the contribution of… read more here.
Keywords: pain; nerve damage; lysophosphatidic acid; nerve ... See more keywords
The effect of lysophosphatidic acid together with interferon tau on the global transcriptomic profile in bovine endometrial cells.
Sign Up to like & getrecommendations! Published in 2017 at "Theriogenology"
DOI: 10.1016/j.theriogenology.2017.01.021
Abstract: In cows, lysophosphatidic acid (LPA), which acts in an auto/paracrine manner, serves as a luteotropic factor during early pregnancy by stimulating progesterone and prostaglandin E2 secretion, thus protecting the bovine corpus luteum and early embryo… read more here.
Keywords: pregnancy; endometrial cells; lysophosphatidic acid; interferon tau ... See more keywords
Progress in Detection of Biomarker of Ovarian Cancer: Lysophosphatidic Acid
Sign Up to like & getrecommendations! Published in 2020 at "Chinese Journal of Analytical Chemistry"
DOI: 10.1016/s1872-2040(20)60062-7
Abstract: Abstract Ovarian cancer is a serious threat to women's health, and its mortality rate is the highest in gynecological cancer. At present, there is a lack of effective and convenient early diagnosis techniques for ovarian… read more here.
Keywords: cancer; progress detection; ovarian cancer; lysophosphatidic acid ... See more keywords