YY1 cooperates with TFEB to regulate autophagy and lysosomal biogenesis in melanoma
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.23105
Abstract: Autophagy is a self‐proteolytic process that degrades intracellular material to maintain cellular homeostasis. Transcription factor EB (TFEB) is the master activator that regulates the transcription of genes involved in autophagy and lysosomal biogenesis. However, the… read more here.
Keywords: biogenesis; autophagy lysosomal; yy1 cooperates; biogenesis melanoma ... See more keywords
Atherosclerosis: Trehalose induces macrophage autophagy–lysosomal biogenesis
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Cardiology"
DOI: 10.1038/nrcardio.2017.97
Abstract: autophagy-lysosomal biogenesis as a therapy for atherosclerosis. Nat. Comms. 8, 15750 (2017) The development of atherosclerotic plaques is characterized by progressive macrophage autophagy–lysosomal dysfunction. According to a new study by Sergin et al. published in… read more here.
Keywords: autophagy lysosomal; atherosclerosis; macrophage; lysosomal biogenesis ... See more keywords
Gastrodin induces lysosomal biogenesis and autophagy to prevent the formation of foam cells via AMPK‐FoxO1‐TFEB signalling axis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16600
Abstract: Abnormal accumulation of lipids and massive deposition of foam cells is a primary event in the pathogenesis of atherosclerosis. Recent studies have demonstrated that autophagy and lysosomal function of atherosclerotic macrophages are impaired, which exacerbates… read more here.
Keywords: biogenesis autophagy; foam; foam cells; formation foam ... See more keywords
The RBG-1–RBG-2 complex modulates autophagy activity by regulating lysosomal biogenesis and function in C. elegans
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cell Science"
DOI: 10.1242/jcs.234195
Abstract: ABSTRACT Vici syndrome is a severe and progressive multisystem disease caused by mutations in the EPG5 gene. In patient tissues and animal models, loss of EPG5 function is associated with defective autophagy caused by accumulation… read more here.
Keywords: rbg; rbg rbg; rbg complex; function ... See more keywords