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   Articles with "lysosomal ca2" as a keyword



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A cellular protection racket: How lysosomal Ca2+ fluxes prevent kidney injury.

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recommendations! Published in 2020 at "Cell calcium"

DOI: 10.1016/j.ceca.2020.102328

Abstract: LC3-lipidation is activated by lysosomal damage by mechanisms that are unknown and divergent from canonical autophagy. In this study, Nakamura et al, show that lysosomal damage induced by lysosomotropic agents or oxalate in renal proximal… read more here.

Keywords: protection racket; ca2 fluxes; cellular protection; racket lysosomal ... See more keywords

Relevance of lysosomal Ca2+ signalling machinery in cancer.

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recommendations! Published in 2022 at "Cell calcium"

DOI: 10.1016/j.ceca.2022.102539

Abstract: In comparison with normal cells, cancer cells are equipped with a higher number of lysosomes, involved in degradative and non-degradative roles. In particular, the lysosome is a Ca2+signalling hub, and the enhancement of this interconnected… read more here.

Keywords: cancer; ca2 signalling; machinery cancer; ca2 ... See more keywords

Lysosomal Ca2+ Signaling Regulates High Glucose-Mediated Interleukin-1β Secretion via Transcription Factor EB in Human Monocytic Cells

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recommendations! Published in 2017 at "Frontiers in Immunology"

DOI: 10.3389/fimmu.2017.01161

Abstract: Aberrant activation of the innate immune system, including NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome-dependent interleukin-1β (IL-1β) secretion, has been implicated in the pathogenesis of type 2 diabetes mellitus (T2DM) and its complication. Our… read more here.

Keywords: interleukin secretion; human monocytic; ca2; lysosomal ca2 ... See more keywords

TRPML3-mediated lysosomal Ca2+ release enhances drug sequestration and biogenesis, promoting osimertinib resistance in non-small cell lung cancer

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recommendations! Published in 2025 at "Oncology Reports"

DOI: 10.3892/or.2025.8946

Abstract: Lysosomes and lysosomal Ca2+ play crucial roles in cellular homeostasis and drug resistance. The lysosomal Ca2+ channel transient receptor potential mucolipin 3 (TRPML3; also known as mucolipin-3 or MCOLN3) is a key regulator of autophagy… read more here.

Keywords: resistance; drug; cell; lysosomal ca2 ... See more keywords