A cellular protection racket: How lysosomal Ca2+ fluxes prevent kidney injury.
Sign Up to like & getrecommendations! Published in 2020 at "Cell calcium"
DOI: 10.1016/j.ceca.2020.102328
Abstract: LC3-lipidation is activated by lysosomal damage by mechanisms that are unknown and divergent from canonical autophagy. In this study, Nakamura et al, show that lysosomal damage induced by lysosomotropic agents or oxalate in renal proximal… read more here.
Keywords: protection racket; ca2 fluxes; cellular protection; racket lysosomal ... See more keywords
Relevance of lysosomal Ca2+ signalling machinery in cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Cell calcium"
DOI: 10.1016/j.ceca.2022.102539
Abstract: In comparison with normal cells, cancer cells are equipped with a higher number of lysosomes, involved in degradative and non-degradative roles. In particular, the lysosome is a Ca2+signalling hub, and the enhancement of this interconnected… read more here.
Keywords: cancer; ca2 signalling; machinery cancer; ca2 ... See more keywords
Lysosomal Ca2+ Signaling Regulates High Glucose-Mediated Interleukin-1β Secretion via Transcription Factor EB in Human Monocytic Cells
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2017.01161
Abstract: Aberrant activation of the innate immune system, including NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome-dependent interleukin-1β (IL-1β) secretion, has been implicated in the pathogenesis of type 2 diabetes mellitus (T2DM) and its complication. Our… read more here.
Keywords: interleukin secretion; human monocytic; ca2; lysosomal ca2 ... See more keywords