Lysosomal ceramides regulate Cathepsin B-mediated processing of saposin C and glucocerebrosidase activity.
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DOI: 10.1093/hmg/ddac047
Abstract: Variants in multiple lysosomal enzymes increase Parkinson's disease risk, including the genes encoding glucocerebrosidase (GCase), acid sphingomyelinase and galactosylceramidase. Each of these enzymes generate ceramide by hydrolysis of sphingolipids in lysosomes, but the role of… read more here.
Keywords: cathepsin; gcase; ceramides regulate; lysosomal ceramides ... See more keywords