Niemann-Pick Type C Disease Reveals a Link between Lysosomal Cholesterol and PtdIns(4,5)P2 That Regulates Neuronal Excitability
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2019.04.099
Abstract: SUMMARY There is increasing evidence that the lysosome is involved in the pathogenesis of a variety of neurodegenerative disorders. Thus, mechanisms that link lysosome dysfunction to the disruption of neuronal homeostasis offer opportunities to understand… read more here.
Keywords: neuronal excitability; niemann pick; lysosomal cholesterol; disease ... See more keywords
The Cholesterol Transport Inhibitor U18666A Interferes with Pseudorabies Virus Infection
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DOI: 10.3390/v14071539
Abstract: Many viruses require the maintenance of lysosomal cholesterol homeostasis for a successful infection; however, the role of lysosomal cholesterol homeostasis in the alphaherpesvirus life cycle is not clear. Here we show that the lysosomal cholesterol… read more here.
Keywords: cholesterol transport; transport inhibitor; infection; u18666a interferes ... See more keywords
Lysosomal cholesterol export reconstituted from fragments of Niemann-Pick C1
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DOI: 10.7554/elife.38564
Abstract: Niemann-Pick C1 (NPC1) is a polytopic membrane protein with 13 transmembrane helices that exports LDL-derived cholesterol from lysosomes by carrying it through the 80 Å glycocalyx and the 40 Å lipid bilayer. Transport begins when… read more here.
Keywords: lysosomal cholesterol; cholesterol; cholesterol export; npc1 ... See more keywords