Acute epileptiform activity induced by gabazine involves proteasomal rather than lysosomal degradation of KCa2.2 channels
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Disease"
DOI: 10.1016/j.nbd.2018.01.005
Abstract: Voltage-independent, Ca2+-activated K+ channels (KCa2.2, previously named SK2) are typically activated during a train of action potentials, and hence, are powerful regulators of cellular excitability by generating an afterhyperpolarizing potential (AHP) following prolonged excitation. In… read more here.
Keywords: protein; degradation; kca2; rather lysosomal ... See more keywords
Biomolecular Ultrasound Imaging of Phagolysosomal Function.
Sign Up to like & getrecommendations! Published in 2020 at "ACS nano"
DOI: 10.1021/acsnano.0c05912
Abstract: Phagocytic clearance and lysosomal processing of pathogens and debris are essential functions of the innate immune system. However, the assessment of these functions in vivo is challenging because most nanoscale contrast agents compatible with non-invasive… read more here.
Keywords: contrast; ultrasound imaging; phagolysosomal function; lysosomal degradation ... See more keywords
Lysosomal degradation of newly formed insulin granules contributes to β cell failure in diabetes
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11170-4
Abstract: Compromised function of insulin-secreting pancreatic β cells is central to the development and progression of Type 2 Diabetes (T2D). However, the mechanisms underlying β cell failure remain incompletely understood. Here, we report that metabolic stress… read more here.
Keywords: insulin; degradation; lysosomal degradation; cell failure ... See more keywords
SPHK1 (sphingosine kinase 1) induces epithelial-mesenchymal transition by promoting the autophagy-linked lysosomal degradation of CDH1/E-cadherin in hepatoma cells
Sign Up to like & getrecommendations! Published in 2017 at "Autophagy"
DOI: 10.1080/15548627.2017.1291479
Abstract: ABSTRACT SPHK1 (sphingosine kinase 1), a regulator of sphingolipid metabolites, plays a causal role in the development of hepatocellular carcinoma (HCC) through augmenting HCC invasion and metastasis. However, the mechanism by which SPHK1 signaling promotes… read more here.
Keywords: cdh1; degradation; sphk1; lysosomal degradation ... See more keywords
The polyphenol EGCG directly targets intracellular amyloid-β aggregates and promotes their lysosomal degradation.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of neurochemistry"
DOI: 10.1111/jnc.15842
Abstract: The accumulation of amyloidogenic protein aggregates in neurons is a pathogenic hallmark of a large number of neurodegenerative diseases including Alzheimer's disease (AD). Small molecules targeting such structures and promoting their degradation may have therapeutic… read more here.
Keywords: egcg directly; directly targets; amyloid aggregates; lysosomal degradation ... See more keywords