GSK-3β inhibition elicits a neuroprotection by restoring lysosomal dysfunction in neurons via facilitation of TFEB nuclear translocation after ischemic stroke
Sign Up to like & getrecommendations! Published in 2021 at "Brain research"
DOI: 10.1016/j.brainres.2021.147768
Abstract: Lysosomal dysfunction is an essential pathogenesis of autophagic neuronal injury after ischemic stroke. As a result of cerebral ischemia, transcription factor EB (TFEB) is greatly phosphorylated by prominently activated glycogen synthase kinase-3β (GSK-3β). This increased… read more here.
Keywords: ischemic stroke; inhibition; lysosomal dysfunction; gsk inhibition ... See more keywords
Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2017.09.005
Abstract: Endo-lysosomal pathways are essential in maintaining protein homeostasis in the cell. Numerous genes in the endo-lysosomal pathways have been found to associate with neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and frontotemporal dementia… read more here.
Keywords: endo lysosomal; dysfunction; neurodegenerative diseases; lysosomal dysfunction ... See more keywords
Epigenetic regulator BRD4 is involved in cadmium-induced acute kidney injury via contributing to lysosomal dysfunction, autophagy blockade and oxidative stress.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2021.127110
Abstract: Cadmium (Cd) is a known nephrotoxic heavy metal and proximal tubules are the major target of Cd-induced acute kidney injury (AKI). We previously demonstrated that lysosomal dysfunction and dysregulated autophagy contribute to Cd-induced AKI. Recent… read more here.
Keywords: lysosomal dysfunction; brd4; autophagy; oxidative stress ... See more keywords
Drp1/Fis1-mediated mitochondrial fragmentation leads to lysosomal dysfunction in cardiac models of Huntington's disease.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2018.12.004
Abstract: Huntington's disease (HD) is a fatal hereditary neurodegenerative disorder, best known for its clinical triad of progressive motor impairment, cognitive deficits and psychiatric disturbances, is caused by CAG-repeat expansion in exon 1 of Huntingtin (HTT).… read more here.
Keywords: dysfunction; disease; fis1 mediated; drp1 fis1 ... See more keywords
Downregulation of Histone H4 Lysine 16 Acetylation Ameliorates Autophagic Flux by Resuming Lysosomal Functions in Ischemic Neurons.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.3c00049
Abstract: Autophagic/lysosomal dysfunction was a critical pathogenesis of neuronal death after an ischemic stroke, but what drove the impairment of autophagic flux remained elusive. Studies indicated that histone H4 lysine 16 acetylation (H4K16ac) drastically modulated the… read more here.
Keywords: autophagic lysosomal; h4k16ac; lysosomal dysfunction; autophagic flux ... See more keywords
Molecular Engineering of pH-Responsive NIR Oxazine Assemblies for Evoking Tumor Ferroptosis via Triggering Lysosomal Dysfunction.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c13222
Abstract: Ferroptosis, a newly discovered form of regulated cell death, is emerging as a promising approach to tumor therapy. However, the spatiotemporal control of cell-intrinsic Fenton chemistry to modulate tumor ferroptosis remains challenging. Here, we report… read more here.
Keywords: biotin; lysosomal dysfunction; tumor; oxazine ... See more keywords
Senescence-associated lysosomal dysfunction impairs cystine deprivation-induced lipid peroxidation and ferroptosis
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-61894-9
Abstract: Senescent cells, characterized by irreversible cell cycle arrest and inflammatory factor secretion, promote various age-related pathologies. Senescent cells exhibit resistance to ferroptosis, a form of iron-dependent cell death; however, the underlying mechanisms remain unclear. Here,… read more here.
Keywords: lipid peroxidation; senescent cells; peroxidation ferroptosis; lysosomal dysfunction ... See more keywords
A malondialdehyde-activated fluorescent probe reveals lysosomal dysfunction in atherosclerosis
Sign Up to like & getrecommendations! Published in 2025 at "Chemical Science"
DOI: 10.1039/d5sc04487a
Abstract: Lysosomes, serving as the digestive centers in cells, play a crucial role in lipid metabolism, inflammatory regulation, and cellular homeostasis. The bidirectional vicious cycle between lysosomal dysfunction and oxidative stress synergistically promotes the occurrence, development… read more here.
Keywords: atherosclerosis; activated fluorescent; malondialdehyde activated; lysosomal dysfunction ... See more keywords
Use of acidic nanoparticles to rescue macrophage lysosomal dysfunction in atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2108252
Abstract: ABSTRACT Dysfunction in the macrophage lysosomal system including reduced acidity and diminished degradative capacity is a hallmark of atherosclerosis, leading to blunted clearance of excess cellular debris and lipids in plaques and contributing to lesion… read more here.
Keywords: acidic nanoparticles; rescue macrophage; lysosomal dysfunction; macrophage ... See more keywords
Endo-lysosomal dysfunction in neurodegenerative diseases: opinion on current progress and future direction in the use of exosomes as biomarkers
Sign Up to like & getrecommendations! Published in 2024 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2022.0387
Abstract: Over the past two decades, increased research has highlighted the connection between endosomal trafficking defects and neurodegeneration. The endo-lysosomal network is an important, complex cellular system specialized in the transport of proteins, lipids, and other… read more here.
Keywords: disease; endo lysosomal; opinion; lysosomal dysfunction ... See more keywords
Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aam9080
Abstract: Human-derived neurons provide the answers Pathways involved in energy metabolism and removal of cellular debris by lysosomes play an important role in protecting our brain from degeneration in Parkinson's disease. Burbulla et al. identified a… read more here.
Keywords: dysfunction; lysosomal dysfunction; mitochondrial lysosomal; parkinson disease ... See more keywords