GSK-3β inhibition elicits a neuroprotection by restoring lysosomal dysfunction in neurons via facilitation of TFEB nuclear translocation after ischemic stroke
Sign Up to like & getrecommendations! Published in 2021 at "Brain research"
DOI: 10.1016/j.brainres.2021.147768
Abstract: Lysosomal dysfunction is an essential pathogenesis of autophagic neuronal injury after ischemic stroke. As a result of cerebral ischemia, transcription factor EB (TFEB) is greatly phosphorylated by prominently activated glycogen synthase kinase-3β (GSK-3β). This increased… read more here.
Keywords: ischemic stroke; inhibition; lysosomal dysfunction; gsk inhibition ... See more keywords
Endo-lysosomal dysfunction: a converging mechanism in neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2017.09.005
Abstract: Endo-lysosomal pathways are essential in maintaining protein homeostasis in the cell. Numerous genes in the endo-lysosomal pathways have been found to associate with neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), and frontotemporal dementia… read more here.
Keywords: endo lysosomal; dysfunction; neurodegenerative diseases; lysosomal dysfunction ... See more keywords
Epigenetic regulator BRD4 is involved in cadmium-induced acute kidney injury via contributing to lysosomal dysfunction, autophagy blockade and oxidative stress.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2021.127110
Abstract: Cadmium (Cd) is a known nephrotoxic heavy metal and proximal tubules are the major target of Cd-induced acute kidney injury (AKI). We previously demonstrated that lysosomal dysfunction and dysregulated autophagy contribute to Cd-induced AKI. Recent… read more here.
Keywords: lysosomal dysfunction; brd4; autophagy; oxidative stress ... See more keywords
Drp1/Fis1-mediated mitochondrial fragmentation leads to lysosomal dysfunction in cardiac models of Huntington's disease.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of molecular and cellular cardiology"
DOI: 10.1016/j.yjmcc.2018.12.004
Abstract: Huntington's disease (HD) is a fatal hereditary neurodegenerative disorder, best known for its clinical triad of progressive motor impairment, cognitive deficits and psychiatric disturbances, is caused by CAG-repeat expansion in exon 1 of Huntingtin (HTT).… read more here.
Keywords: dysfunction; disease; fis1 mediated; drp1 fis1 ... See more keywords
Downregulation of Histone H4 Lysine 16 Acetylation Ameliorates Autophagic Flux by Resuming Lysosomal Functions in Ischemic Neurons.
Sign Up to like & getrecommendations! Published in 2023 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.3c00049
Abstract: Autophagic/lysosomal dysfunction was a critical pathogenesis of neuronal death after an ischemic stroke, but what drove the impairment of autophagic flux remained elusive. Studies indicated that histone H4 lysine 16 acetylation (H4K16ac) drastically modulated the… read more here.
Keywords: autophagic lysosomal; h4k16ac; lysosomal dysfunction; autophagic flux ... See more keywords
Molecular Engineering of pH-Responsive NIR Oxazine Assemblies for Evoking Tumor Ferroptosis via Triggering Lysosomal Dysfunction.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.2c13222
Abstract: Ferroptosis, a newly discovered form of regulated cell death, is emerging as a promising approach to tumor therapy. However, the spatiotemporal control of cell-intrinsic Fenton chemistry to modulate tumor ferroptosis remains challenging. Here, we report… read more here.
Keywords: biotin; lysosomal dysfunction; tumor; oxazine ... See more keywords
Use of acidic nanoparticles to rescue macrophage lysosomal dysfunction in atherosclerosis
Sign Up to like & getrecommendations! Published in 2022 at "Autophagy"
DOI: 10.1080/15548627.2022.2108252
Abstract: ABSTRACT Dysfunction in the macrophage lysosomal system including reduced acidity and diminished degradative capacity is a hallmark of atherosclerosis, leading to blunted clearance of excess cellular debris and lipids in plaques and contributing to lesion… read more here.
Keywords: acidic nanoparticles; rescue macrophage; lysosomal dysfunction; macrophage ... See more keywords
Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2017 at "Science"
DOI: 10.1126/science.aam9080
Abstract: Human-derived neurons provide the answers Pathways involved in energy metabolism and removal of cellular debris by lysosomes play an important role in protecting our brain from degeneration in Parkinson's disease. Burbulla et al. identified a… read more here.
Keywords: dysfunction; lysosomal dysfunction; mitochondrial lysosomal; parkinson disease ... See more keywords
Autophagic and endo-lysosomal dysfunction in neurodegenerative disease
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Brain"
DOI: 10.1186/s13041-019-0504-x
Abstract: Due to their post-mitotic state, metabolic demands and often large polarised morphology, the function and survival of neurons is dependent on an efficient cellular waste clearance system both for generation of materials for metabolic processes… read more here.
Keywords: autophagic endo; disease; lysosomal dysfunction; clearance ... See more keywords
Lysosomal dysfunction in TMEM106B hypomyelinating leukodystrophy
Sign Up to like & getrecommendations! Published in 2018 at "Neurology: Genetics"
DOI: 10.1212/nxg.0000000000000288
Abstract: Transmembrane protein 106B (TMEM106B; NM_001134232) was recently identified as a gene responsible for a form of hypomyelinating leukodystrophy (HLD).1,2 All 5 cases identified to date carry the identical c.754 G > A, (p.Asp252Asn) mutation.1,2 Although… read more here.
Keywords: hypomyelinating leukodystrophy; dysfunction tmem106b; tmem106b; biology ... See more keywords
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases
Sign Up to like & getrecommendations! Published in 2017 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.201606965
Abstract: Lysosomal storage disorders (LSDs) are inherited diseases characterized by lysosomal dysfunction and often showing a neurodegenerative course. There is no cure to treat the central nervous system in LSDs. Moreover, the mechanisms driving neuronal degeneration… read more here.
Keywords: lysosomal storage; dysfunction; presynaptic function; neurodegeneration ... See more keywords