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Published in 2020 at "Journal of Materials Science"
DOI: 10.1007/s10853-020-05515-4
Abstract: A receptor-mediated, active-targeting and glutathione (GSH) turn-on charge-reversal core/shell nanocomplex HA-MEA-s-s-TGA/PAMAM@DOX was constructed to achieve increased stability, improved cellular uptake, facilitated endo-lysosomal escape and enhanced antitumor efficacy. This nanocomplex was composed of anionic hyaluronic acid…
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Keywords:
lysosomal escape;
facilitated endo;
dox;
shell ... See more keywords
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Published in 2018 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b11972
Abstract: Nowadays, efficient endo/lysosomal escape and the subsequent release of drugs into the cytosol are the major obstacles for nanoplatform-based cancer therapy. Herein, we first report a metal-organic framework-based nanoplatform (doxorubicin@ZIF-8@AS1411) for intracellular environment-responsive endo/lysosomal escape…
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Keywords:
cancer;
endo lysosomal;
cancer therapy;
lysosomal escape ... See more keywords