Destroy the old to build the new: Activity-dependent lysosomal exocytosis in neurons
Sign Up to like & getrecommendations! Published in 2021 at "Neuroscience Research"
DOI: 10.1016/j.neures.2021.03.011
Abstract: Lysosomes are organelles that support diverse cellular functions such as terminal degradation of macromolecules and nutrient recycling. Additionally, lysosomes can fuse with the plasma membrane, a phenomenon referred to as lysosomal exocytosis, to release their… read more here.
Keywords: build new; destroy old; old build; lysosomal exocytosis ... See more keywords
Spatial organization of lysosomal exocytosis relies on membrane tension gradients.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2207425120
Abstract: Lysosomal exocytosis is involved in many key cellular processes but its spatiotemporal regulation is poorly known. Using total internal reflection fluorescence microscopy (TIRFM) and spatial statistics, we observed that lysosomal exocytosis is not random at… read more here.
Keywords: lysosomal exocytosis; exocytosis; membrane tension; microscopy ... See more keywords
TFEB-mediated lysosomal exocytosis alleviates high-fat diet–induced lipotoxicity in the kidney
Sign Up to like & getrecommendations! Published in 2023 at "JCI Insight"
DOI: 10.1172/jci.insight.162498
Abstract: Obesity is a major risk factor for end-stage kidney disease. We previously found that lysosomal dysfunction and impaired autophagic flux contribute to lipotoxicity in obesity-related kidney disease, in both humans and experimental animal models. However,… read more here.
Keywords: tfeb; lysosomal exocytosis; mediated lysosomal; kidney ... See more keywords
Lysosomal accumulation of anticancer drugs triggers lysosomal exocytosis
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.15155
Abstract: We have recently shown that hydrophobic weak base anticancer drugs are highly sequestered in acidic lysosomes, inducing TFEB-mediated lysosomal biogenesis and markedly increased lysosome numbers per cell. This enhanced lysosomal sequestration of chemotherapeutics, away from… read more here.
Keywords: accumulation; drug; anticancer drugs; lysosomal exocytosis ... See more keywords