Ca2+-Dependent Regulation of TFEB and Lysosomal Function.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9018-4_13
Abstract: Lysosomes are emerging as calcium store organelles that can modulate various intracellular processes such as the regulation of nutrient signaling through the activation of TFEB, a master gene for lysosomal function, or very specialized functions… read more here.
Keywords: tfeb; ca2 dependent; tfeb lysosomal; lysosomal function ... See more keywords
Preserving Lysosomal Function in the Aging Brain: Insights from Neurodegeneration
Sign Up to like & getrecommendations! Published in 2019 at "Neurotherapeutics"
DOI: 10.1007/s13311-019-00742-3
Abstract: Lysosomes are acidic, membrane-bound organelles that serve as the primary catabolic compartment of the cell. They are crucial to a variety of cellular processes from nutrient storage to autophagy. Given the diversity of lysosomal functions,… read more here.
Keywords: preserving lysosomal; aging brain; function; lysosomal function ... See more keywords
UVA-induced photoaging inhibits autophagic degradation by impairing lysosomal function in dermal fibroblasts.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.08.103
Abstract: Autophagy has been associated with a variety of diseases especially aging. Human dermal fibroblasts (HDFs) can internalize and then degrade elastin, collagen and advanced glycation end products (AGEs) in lysosomes, which plays prominent roles in… read more here.
Keywords: degradation; uva induced; induced photoaging; photoaged fibroblasts ... See more keywords
Mild hypothermia protects hippocampal neurons against oxygen‐glucose deprivation/reperfusion‐induced injury by improving lysosomal function and autophagic flux
Sign Up to like & getrecommendations! Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.06.010
Abstract: ABSTRACT Mild hypothermia has been proven to be useful to treat brain ischemia/reperfusion injury. However, the underlying mechanisms have not yet been fully elucidated. The present study was undertaken to determine whether mild hypothermia protects… read more here.
Keywords: hippocampal neurons; mild hypothermia; hypothermia; autophagic flux ... See more keywords
Apelin-13 exerts protective effects against acute kidney injury by lysosomal function regulation
Sign Up to like & getrecommendations! Published in 2025 at "Renal Failure"
DOI: 10.1080/0886022x.2025.2480243
Abstract: Abstract Background Recent studies suggest that the loss of lysosomal function is associated with acute kidney injury (AKI), potentially leading to impaired autophagy. Apelin has been known to regulate autophagy processes in cardiovascular and pulmonary… read more here.
Keywords: kidney injury; acute kidney; kidney; lysosomal function ... See more keywords
Restoration of lysosomal function attenuates autophagic flux impairment in nucleus pulposus cells and protects against mechanical overloading-induced intervertebral disc degeneration
Sign Up to like & getrecommendations! Published in 2024 at "Autophagy"
DOI: 10.1080/15548627.2024.2440844
Abstract: ABSTRACT Intervertebral disc degeneration (IVDD) is a leading cause of low back pain that incurs large socioeconomic burdens. Growing evidence reveals that macroautophagy/autophagy dysregulation contributes to IVDD, but the exact role of autophagy and its… read more here.
Keywords: disc degeneration; intervertebral disc; autophagic flux; mechanical overloading ... See more keywords
Acidic nanoparticles protect against α‐synuclein‐induced neurodegeneration through the restoration of lysosomal function
Sign Up to like & getrecommendations! Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13584
Abstract: Parkinson's disease (PD) is an age‐related neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, associated with the accumulation of misfolded α‐synuclein and lysosomal impairment, two events deemed interconnected. Protein aggregation… read more here.
Keywords: acidic nanoparticles; nanoparticles protect; lysosomal function; synuclein ... See more keywords
The phytochemical polydatin ameliorates non‐alcoholic steatohepatitis by restoring lysosomal function and autophagic flux
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14320
Abstract: Impaired autophagic degradation of intracellular lipids is causally linked to the development of non‐alcoholic steatohepatitis (NASH). Pharmacological agents that can restore hepatic autophagic flux could therefore have therapeutic potentials for this increasingly prevalent disease. Herein,… read more here.
Keywords: non alcoholic; alcoholic steatohepatitis; autophagic flux; polydatin ... See more keywords
Cyclosporine A blocks autophagic flux in tubular epithelial cells by impairing TFEB‐mediated lysosomal function
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16593
Abstract: Cyclosporine A (CsA) is an immunosuppressor widely used for the prevention of acute rejection during solid organ transplantation. However, severe nephrotoxicity has substantially limited its long‐term usage. Recently, an impaired autophagy pathway was suggested to… read more here.
Keywords: epithelial cells; tfeb mediated; tubular epithelial; cyclosporine ... See more keywords
Free fatty acid exacerbates diabetic kidney injury by suppressing autophagy-lysosomal function via ER stress
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733227
Abstract: Diabetic kidney disease (DKD), the leading cause of chronic kidney disease, is characterized by accumulation of renal tubule free fatty acids (FFAs) and triglyceride (TG)-enriched lipid droplets (LDs) and cell death. The present study aimed… read more here.
Keywords: cell; lysosomal function; kidney; physiology ... See more keywords
Inhibition of Lysosomal Function Mitigates Protective Mitophagy and Augments Ceramide Nanoliposome–Induced Cell Death in Head and Neck Squamous Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-20-0182
Abstract: Therapies for head and neck squamous cell carcinoma (HNSCC) are, at best, moderately effective, underscoring the need for new therapeutic strategies. Ceramide treatment leads to cell death as a consequence of mitochondrial damage by generating… read more here.
Keywords: cell death; lysosomal function; mitophagy; cell ... See more keywords