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Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9018-4_13
Abstract: Lysosomes are emerging as calcium store organelles that can modulate various intracellular processes such as the regulation of nutrient signaling through the activation of TFEB, a master gene for lysosomal function, or very specialized functions…
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Keywords:
tfeb;
ca2 dependent;
tfeb lysosomal;
lysosomal function ... See more keywords
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Published in 2019 at "Neurotherapeutics"
DOI: 10.1007/s13311-019-00742-3
Abstract: Lysosomes are acidic, membrane-bound organelles that serve as the primary catabolic compartment of the cell. They are crucial to a variety of cellular processes from nutrient storage to autophagy. Given the diversity of lysosomal functions,…
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Keywords:
preserving lysosomal;
aging brain;
function;
lysosomal function ... See more keywords
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Published in 2019 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2019.08.103
Abstract: Autophagy has been associated with a variety of diseases especially aging. Human dermal fibroblasts (HDFs) can internalize and then degrade elastin, collagen and advanced glycation end products (AGEs) in lysosomes, which plays prominent roles in…
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Keywords:
degradation;
uva induced;
induced photoaging;
photoaged fibroblasts ... See more keywords
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Published in 2017 at "Experimental Cell Research"
DOI: 10.1016/j.yexcr.2017.06.010
Abstract: ABSTRACT Mild hypothermia has been proven to be useful to treat brain ischemia/reperfusion injury. However, the underlying mechanisms have not yet been fully elucidated. The present study was undertaken to determine whether mild hypothermia protects…
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Keywords:
hippocampal neurons;
mild hypothermia;
hypothermia;
autophagic flux ... See more keywords
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Published in 2022 at "Aging Cell"
DOI: 10.1111/acel.13584
Abstract: Parkinson's disease (PD) is an age‐related neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, associated with the accumulation of misfolded α‐synuclein and lysosomal impairment, two events deemed interconnected. Protein aggregation…
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Keywords:
acidic nanoparticles;
nanoparticles protect;
lysosomal function;
synuclein ... See more keywords
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Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14320
Abstract: Impaired autophagic degradation of intracellular lipids is causally linked to the development of non‐alcoholic steatohepatitis (NASH). Pharmacological agents that can restore hepatic autophagic flux could therefore have therapeutic potentials for this increasingly prevalent disease. Herein,…
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Keywords:
non alcoholic;
alcoholic steatohepatitis;
autophagic flux;
polydatin ... See more keywords
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Published in 2021 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.16593
Abstract: Cyclosporine A (CsA) is an immunosuppressor widely used for the prevention of acute rejection during solid organ transplantation. However, severe nephrotoxicity has substantially limited its long‐term usage. Recently, an impaired autophagy pathway was suggested to…
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Keywords:
epithelial cells;
tfeb mediated;
tubular epithelial;
cyclosporine ... See more keywords
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Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733227
Abstract: Diabetic kidney disease (DKD), the leading cause of chronic kidney disease, is characterized by accumulation of renal tubule free fatty acids (FFAs) and triglyceride (TG)-enriched lipid droplets (LDs) and cell death. The present study aimed…
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Keywords:
cell;
lysosomal function;
kidney;
physiology ... See more keywords
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Published in 2020 at "Molecular Cancer Therapeutics"
DOI: 10.1158/1535-7163.mct-20-0182
Abstract: Therapies for head and neck squamous cell carcinoma (HNSCC) are, at best, moderately effective, underscoring the need for new therapeutic strategies. Ceramide treatment leads to cell death as a consequence of mitochondrial damage by generating…
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Keywords:
cell death;
lysosomal function;
mitophagy;
cell ... See more keywords
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Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.821719
Abstract: Protein Signaling Domains Laboratory, Department of Biological Sciences, Fralin Life Sciences Institute, and Center for Soft Matter and Biological Physics, Virginia Tech, Blacksburg, VA, United States, Medical Research Institute Mercedes and Martín Ferreyra (INIMEC-CONICET-UNC), Córdoba,…
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Keywords:
proteins endosomal;
endosomal lysosomal;
groningen;
editorial signaling ... See more keywords