Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics
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DOI: 10.1093/nar/gkad023
Abstract: Abstract Inefficient endosomal escape remains the primary barrier to the broad application of oligonucleotide therapeutics. Liver uptake after systemic administration is sufficiently robust that a therapeutic effect can be achieved but targeting extrahepatic tissues remains… read more here.
Keywords: fusion; lysosomal fusion; endocytic recycling; activity ... See more keywords