Could an endo-lysosomal ion channel be the Achilles heel of SARS-CoV2?
Sign Up to like & getrecommendations! Published in 2020 at "Cell Calcium"
DOI: 10.1016/j.ceca.2020.102212
Abstract: Abstract The ongoing SARS-CoV2 outbreak has developed into a global pandemic. Despite previous outbreaks of SARS-CoV and the related MERS-CoV in recent years, neither a vaccine nor any other medication for an effective treatment are… read more here.
Keywords: could endo; ion channel; sars cov2; channel achilles ... See more keywords
Lysosomal Ion Channels: What Are They Good For and Are They Druggable Targets?
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of pharmacology and toxicology"
DOI: 10.1146/annurev-pharmtox-051921-013755
Abstract: Lysosomes play fundamental roles in material digestion, cellular clearance, recycling, exocytosis, wound repair, Ca2+ signaling, nutrient signaling, and gene expression regulation. The organelle also serves as a hub for important signaling networks involving the mTOR… read more here.
Keywords: toxicology; channels good; pharmacology; lysosomal ion ... See more keywords