Low‐level lysosomal membrane permeabilization for limited release and sublethal functions of cathepsin proteases in the cytosol and nucleus
Sign Up to like & getrecommendations! Published in 2022 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13385
Abstract: For a long time, lysosomes were purely seen as organelles in charge of garbage disposal within the cell. They destroy any cargo delivered into their lumen with a plethora of highly potent hydrolytic enzymes, including… read more here.
Keywords: level lysosomal; cytosol nucleus; low level; cathepsin proteases ... See more keywords
Lysosomal membrane permeabilization causes secretion of IL-1β in human vascular smooth muscle cells
Sign Up to like & getrecommendations! Published in 2018 at "Inflammation Research"
DOI: 10.1007/s00011-018-1178-z
Abstract: ObjectiveIL-1β secretion by the inflammasome is strictly controlled and requires two sequential signals: a priming signal and an activating signal. Lysosomal membrane permeabilization (LMP) plays a critical role in the regulation of NLRP3 inflammasome, and… read more here.
Keywords: secretion; vascular smooth; human vascular; lysosomal membrane ... See more keywords
A novel tool for detecting lysosomal membrane permeabilization by high-throughput fluorescence microscopy.
Sign Up to like & getrecommendations! Published in 2021 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2020.10.004
Abstract: Lysosomes are placed at the center of cellular trafficking and degradative pathways. They also function as a signaling platform for nutrient sensing and metabolic reprogramming. Lysosomes play crucial roles in cellular adaptation in response to… read more here.
Keywords: microscopy; damaged lysosomes; lysosomal membrane; membrane permeabilization ... See more keywords
Hybrid Magnetic Nanovectors Promote Selective Glioblastoma Cell Death through a Combined Effect of Lysosomal Membrane Permeabilization and Chemotherapy
Sign Up to like & getrecommendations! Published in 2020 at "ACS Applied Materials & Interfaces"
DOI: 10.1021/acsami.0c05556
Abstract: Glioblastoma multiforme is the most aggressive brain tumor, due to its high invasiveness and genetic heterogeneity. Moreover, the blood–brain barrier prevents many drugs from reaching a therapeutic concentration at the tumor site, and most of… read more here.
Keywords: blood brain; glioblastoma; lysosomal membrane; membrane permeabilization ... See more keywords
Dual stimuli-responsive cross-linked nanoassemblies from an amphiphilic mannose-6-phosphate based tri-block copolymer for lysosomal membrane permeabilization.
Sign Up to like & getrecommendations! Published in 2023 at "Biomaterials science"
DOI: 10.1039/d2bm02110b
Abstract: Stimuli-responsive cross-linked nanocarriers that can induce lysosomal cell death (LCD) via lysosomal membrane permeabilization (LMP) represent a new class of delivery platforms and have attracted the attention of researchers in the biomedical field. The advantages… read more here.
Keywords: cross linked; membrane permeabilization; tri block; lysosomal membrane ... See more keywords
ACOD1-mediated lysosomal membrane permeabilization contributes to Mycobacterium tuberculosis–induced macrophage death
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2425309122
Abstract: Significance Here, we show that when Mtb induces macrophages to express interferon-β (IFN-β), they overexpress an enzyme called ACOD1 normally found in mitochondria, whose product, itaconate, protects the cells. Surprisingly, that protective effect is overwhelmed… read more here.
Keywords: membrane permeabilization; lysosomal membrane; permeabilization contributes; mediated lysosomal ... See more keywords
Carboranyl-1,8-naphthalimide intercalators induce lysosomal membrane permeabilization and ferroptosis in cancer cell lines
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2023.2171028
Abstract: Abstract The synthesis of carborane-1,8-naphthalimide conjugates and evaluation of their DNA-binding ability and anticancer activity were performed. A series of 4-carboranyl-3-nitro-1,8-naphthalimide derivatives, mitonafide and pinafide analogs, were synthesised via amidation and reductive amination reactions, and… read more here.
Keywords: cell; membrane; membrane permeabilization; lysosomal membrane ... See more keywords
Azithromycin enhances the cytotoxicity of DNA‐damaging drugs via lysosomal membrane permeabilization in lung cancer cells
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Science"
DOI: 10.1111/cas.14992
Abstract: Cancer cells use autophagy for growth, survival, and cytoprotection from chemotherapy. Therefore, autophagy inhibitors appear to be good candidates for cancer treatment. Our group previously reported that macrolide antibiotics, especially azithromycin (AZM), have potent autophagy… read more here.
Keywords: damaging drugs; dna damaging; treatment; lysosomal membrane ... See more keywords
Therapeutic advantage of targeting lysosomal membrane integrity supported by lysophagy in malignant glioma
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15451
Abstract: Lysosomes function as the digestive system of a cell and are involved in macromolecular recycling, vesicle trafficking, metabolic reprogramming, and progrowth signaling. Although quality control of lysosome biogenesis is thought to be a potential target… read more here.
Keywords: supported lysophagy; membrane integrity; integrity supported; lysosomal membrane ... See more keywords
Abstract We121: Doxorubicin-Induced Cardiomyocyte Death is mediated by Lysosomal Membrane Permeabilization
Sign Up to like & getrecommendations! Published in 2024 at "Circulation Research"
DOI: 10.1161/res.135.suppl_1.we121
Abstract: Doxorubicin (DOX) is a potent antineoplastic drug with broad-spectrum capabilities. However, its clinical use is hindered by dose-dependent cardiotoxicity, often leading to heart failure. This study investigates the connection between DOX-induced cardiotoxicity and lysosomal dysfunction,… read more here.
Keywords: dox; lysosomal membrane; cardiotoxicity; cardiomyocyte death ... See more keywords
(-)-Oleocanthal and (-)-oleocanthal-rich olive oils induce lysosomal membrane permeabilization in cancer cells
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0216024
Abstract: (-)-Oleocanthal (oleocanthal) is a phenolic compound found in varying concentrations in extra virgin olive oil oleocanthal has been shown to be active physiologically, benefiting several diseased states by conferring anti-inflammatory and neuroprotective benefits. Recently, we… read more here.
Keywords: lysosomal membrane; membrane permeabilization; cancer cells; cancer ... See more keywords