Research progress on the effect of autophagy-lysosomal pathway on tumor drug resistance.
Sign Up to like & getrecommendations! Published in 2020 at "Experimental cell research"
DOI: 10.1016/j.yexcr.2020.111925
Abstract: Autophagy is an intracellular degradation pathway that is highly conserved during the evolution of eukaryotes and is based on lysosome. Under nutritional deficiencies or stress, cells can clear damaged and necrotic organelles and proteins through… read more here.
Keywords: drug resistance; lysosomal pathway; autophagy lysosomal; pathway tumor ... See more keywords
Modeling Parkinson's disease in LRRK2 mice: focus on synaptic dysfunction and the autophagy-lysosomal pathway.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical Society transactions"
DOI: 10.1042/bst20211288
Abstract: Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with familial and sporadic forms of Parkinson's disease (PD), for which the LRRK2 locus itself represents a risk factor. Idiopathic and LRRK2-related PD share… read more here.
Keywords: lrrk2 mutants; lysosomal pathway; parkinson disease; lrrk2 ... See more keywords
HSPA5 Promotes Attachment and Internalization of Porcine Epidemic Diarrhea Virus through Interaction with the Spike Protein and the Endo-/Lysosomal Pathway
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Virology"
DOI: 10.1128/jvi.00549-23
Abstract: PEDV infection causes severe piglet mortality and threatens the global pig industry. However, the complex invasion mechanism of PEDV makes its prevention and control difficult. ABSTRACT Porcine epidemic diarrhea virus (PEDV) has caused huge economic… read more here.
Keywords: internalization; lysosomal pathway; infection; hspa5 ... See more keywords
Exendin-4 Attenuates Hepatic Steatosis by Promoting the Autophagy-Lysosomal Pathway
Sign Up to like & getrecommendations! Published in 2022 at "BioMed Research International"
DOI: 10.1155/2022/4246086
Abstract: Dysregulated hepatic steatosis may lead to chronic liver inflammation and nonalcoholic steatohepatitis (NASH). Recent studies have suggested that exendin-4, a glucagon-like peptide-1 agonist, may be a promising therapeutic for hepatic steatosis and NASH. However, the… read more here.
Keywords: lysosomal pathway; steatosis; hepatic steatosis; exendin ... See more keywords
Microglia regulate brain Progranulin levels through the endocytosis-lysosomal pathway.
Sign Up to like & getrecommendations! Published in 2021 at "JCI insight"
DOI: 10.1172/jci.insight.136147
Abstract: Genetic variants in Granulin (GRN), which encodes the secreted glycoprotein Progranulin (PGRN), are associated with several neurodegenerative diseases including frontotemporal lobar degeneration, neuronal ceroid lipofuscinosis, and Alzheimer's disease. These genetic alterations manifest in pathological changes… read more here.
Keywords: endocytosis lysosomal; lysosomal pathway; progranulin; pgrn ... See more keywords
Spatial heterogeneity and Immune infiltration of cellular lysosomal pathways reveals a new blueprint for tumor heterogeneity in esophageal cancer
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2023.1138457
Abstract: Background Esophageal squamous cell carcinoma (ESCC) is a common Malignant tumor of digestive tract which have a potential association with lysosomal pathway. The purpose of this study was to explore the correlation between lysosome pathway… read more here.
Keywords: cell; lysosomal pathway; escc; immune infiltration ... See more keywords
Contribution of Autophagy-Lysosomal Pathway in the Exosomal Secretion of Alpha-Synuclein and Its Impact in the Progression of Parkinson’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.805087
Abstract: Parkinson’s disease (PD) is caused by the degeneration of dopaminergic neurons due to an accumulation of intraneuronal abnormal alpha-synuclein (α-syn) protein aggregates. It has been reported that the levels of exosomal α-syn of neuronal origin… read more here.
Keywords: lysosomal pathway; secretion; alpha synuclein; parkinson disease ... See more keywords
Targeting microtubules sensitizes drug resistant lung cancer cells to lysosomal pathway inhibitors
Sign Up to like & getrecommendations! Published in 2020 at "Theranostics"
DOI: 10.7150/thno.38729
Abstract: Oncogene-addicted cancers are predominantly driven by specific oncogenic pathways and display initial exquisite sensitivity to designer therapies, but eventually become refractory to treatments. Clear understanding of lung tumorigenic mechanisms is essential for improved therapies. Methods:… read more here.
Keywords: microtubule; lysosomal pathway; pathway; lung cancer ... See more keywords