Lysosomal perturbations in human dopaminergic neurons derived from induced pluripotent stem cells with PARK2 mutation
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DOI: 10.1038/s41598-020-67091-6
Abstract: Mutations in the PARK2 gene encoding parkin, an E3 ubiquitin ligase, are associated with autosomal recessive early-onset Parkinson’s disease (PD). While parkin has been implicated in the regulation of mitophagy and proteasomal degradation, the precise… read more here.
Keywords: human dopaminergic; lysosomal perturbations; pluripotent stem; induced pluripotent ... See more keywords