A novel antimicrobial peptide M1‐8 targets the lysosomal pathway to inhibit autolysosome formation and promote apoptosis in liver cancer cells
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DOI: 10.1111/jcmm.17644
Abstract: Lysosomes, a central regulator of autophagy, play a critical role in tumour growth. Lysosomal protease cathepsin D can initiate apoptosis when released from lysosomes into the cytosol. In this study, we observed that Musca domestica… read more here.
Keywords: novel antimicrobial; apoptosis; antimicrobial peptide; peptide ... See more keywords
The Key Role of Lysosomal Protease Cathepsins in Viral Infections
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DOI: 10.3390/ijms23169089
Abstract: Cathepsins encompass a family of lysosomal proteases that mediate protein degradation and turnover. Although mainly localized in the endolysosomal compartment, cathepsins are also found in the cytoplasm, nucleus, and extracellular space, where they are involved… read more here.
Keywords: cathepsins viral; viral infections; protease cathepsins; role lysosomal ... See more keywords