Updates on the study of lysosomal protein dynamics: possibilities for the clinic
Sign Up to like & getrecommendations! Published in 2023 at "Expert Review of Proteomics"
DOI: 10.1080/14789450.2023.2190515
Abstract: ABSTRACT Introduction The lysosome is the main degradative organelle of almost all mammalian cells, fulfilling important functions in macromolecule recycling, metabolism, and signaling. Lysosomal dysfunction is connected to a continuously growing number of pathologic conditions,… read more here.
Keywords: lysosomal protein; study lysosomal; protein dynamics; patient samples ... See more keywords
Abstract 4815: TMEM9 decreases ER stress-induced misfolded proteins via lysosomal protein degradation
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-4815
Abstract: The endoplasmic reticulum (ER) contributes to various protein modifications such as protein folding. Also, the ER-associated degradation (ERAD) complex removes defective proteins, which prevents the accumulation of misfolded proteins to avoid abnormality of physiological activity.… read more here.
Keywords: lysosomal protein; misfolded proteins; protein degradation; degradation ... See more keywords
Key Prognostic Value of Lysosomal Protein Transmembrane 5 in Kidney Renal Clear Cell Carcinoma
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of General Medicine"
DOI: 10.2147/ijgm.s357013
Abstract: Objective To investigate the significance of lysosomal protein transmembrane 5 (LAPTM5) in kidney renal clear cell carcinoma (KIRC). Methods Bioinformatics analysis as an efficient and accurate method was employed to explore the expression levels, prognostic… read more here.
Keywords: kirc patients; laptm5; lysosomal protein; kidney renal ... See more keywords