Lysosomal trafficking mediated by Arl8b and BORC promotes invasion of cancer cells that survive radiation
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DOI: 10.1038/s42003-020-01339-9
Abstract: Enhanced invasiveness, a critical determinant of metastasis and poor prognosis, has been observed in cancer cells that survive cancer therapy, including radiotherapy. Here, we show that invasiveness in radiation-surviving cancer cells is associated with alterations… read more here.
Keywords: cancer cells; cancer; lysosomal trafficking; arl8b borc ... See more keywords
Unraveling novel roles of the Mycobacterium tuberculosis transcription factor Rv0081 in regulation of the nucleoid‐associated proteins Lsr2 and EspR, cholesterol utilization, and subversion of lysosomal trafficking in macrophages
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DOI: 10.1111/mmi.14895
Abstract: The transcriptional network of Mycobacterium tuberculosis is designed to enable the organism to withstand host‐associated stresses and to exploit the host milieu for its own survival and multiplication. Rv0081 (MT0088) is a transcriptional regulator whose… read more here.
Keywords: mycobacterium tuberculosis; lysosomal trafficking; tuberculosis; nucleoid associated ... See more keywords
Isoform-dependent lysosomal degradation and internalization of apolipoprotein E requires autophagy proteins
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DOI: 10.1242/jcs.258687
Abstract: ABSTRACT The human apolipoprotein E4 isoform (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (AD), and lysosomal dysfunction has been implicated in AD pathogenesis. We found, by examining cells stably expressing each… read more here.
Keywords: lysosomal trafficking; apolipoprotein; degradation internalization; autophagy proteins ... See more keywords
Aster‐C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1
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DOI: 10.15252/embr.201949898
Abstract: Nutrient sensing by the mTOR complex 1 (mTORC1) requires its translocation to the lysosomal membrane. Upon amino acids removal, mTORC1 becomes cytosolic and inactive, yet its precise subcellular localization and the mechanism of inhibition remain… read more here.
Keywords: activation mtorc1; aster; mtorc1; cop vesicles ... See more keywords