Efficient Nanobiotechnology Method for Magnetic Lysosome Enrichment Using DMSA-SPMNP 2.0
Sign Up to like & getrecommendations! Published in 2020 at "BioNanoScience"
DOI: 10.1007/s12668-020-00736-y
Abstract: Here, we report an efficient nanobiotechnology method to isolate lysosomal compartments using dimercaptosuccinic acid functionalized superparamagnetic nanoparticles (DMSA-SPMNP 2.0). We synthesized superparamagnetic nanoparticles (SPMNP) using thermal decomposition method followed by dimercaptosuccinic acid (DMSA) surface functionalization… read more here.
Keywords: efficient nanobiotechnology; dmsa spmnp; method; nanobiotechnology method ... See more keywords
Selective Lysosome Membrane Turnover Is Induced by Nutrient Starvation.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.08.008
Abstract: Lysosome function is essential for cellular homeostasis, but quality-control mechanisms that maintain healthy lysosomes remain poorly characterized. Here, we developed a method to measure lysosome turnover and use this to identify a selective mechanism of… read more here.
Keywords: membrane turnover; turnover; lysosome membrane; lysosome ... See more keywords
Mannose-6-phosphate glycan for lysosomal targeting: various applications from enzyme replacement therapy to lysosome-targeting chimeras
Sign Up to like & getrecommendations! Published in 2022 at "Animal Cells and Systems"
DOI: 10.1080/19768354.2022.2079719
Abstract: ABSTRACT A lysosome, an acidic membrane-bound organelle, contains hydrolytic enzymes to digest macromolecules for recycling. Many lysosomal enzymes (LEs) traffic to the lysosome through the mannose-6-phosphate (M6P)-dependent pathway. Some mannose residues of high-mannose type N-glycans… read more here.
Keywords: mannose phosphate; replacement therapy; lysosome; enzyme replacement ... See more keywords